1123495-73-7Relevant academic research and scientific papers
Toward general access to the Aspidosperma-type terpenoid indole alkaloids: Synthesis of the key 3,3-disubstituted piperidones through enantioselective intramolecular Heck-type reaction of chloroformamides
Yasui, Yoshizumi,Takeda, Hiroshi,Takemoto, Yoshiji
experimental part, p. 1567 - 1574 (2009/11/30)
An enantioselective intramolecular Heck-type reaction of chloroformamides has been developed for the synthesis of 3,3-disubstituted piperidones. The desired piperidone was formed in the presence of a palladium catalyst, an optically active phosphoramidite ligand, K3PO4 and Ag 3PO4. The obtained piperidone was converted to epieburnamonine.
