112357-43-4

Upstream product

• 88-89-1 2,4,6-Trinitrophenol 
• 33550-98-0 N-[3-(1⁽³⁾H-imidazol-4-yl)-propyl]-phthalimide 
• 5891-21-4 5-chloro-2-pentanone 
• 3197-25-9 2-(4-oxopentyl)isoindole-1,3-dione 
• 41306-64-3 2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione 
• 84461-00-7 1-diazo-5-phthalimido-2-pentanone 

Relevant academic research and scientific papers

An Alternative Synthesis of Homohistamine and Structurally Related (Imidazole-4-yl)alkylamines

Bromination of N-(4-oxopentyl)phthalimide (3) leads to isomeric bromoketones 2a and 2e, which undergo cyclisation with formamidine in liquid ammonia to yield homohistamine (1a) and 5-methylhistamine (1e).Similarly racemic α-methyl- (1b) and 2-methylhomohistamine (1c) are synthesized.The resolution of 1b is achieved using (+)- and (-)-di-O-(4-toluoyl)tartaric acid. 1 are intermediates in the synthesis of impromidine like, H2-histaminergic compounds. - Key words: Bromination of Methylketones, Halomethylketones, Histamine H2-Agonists, Homohistamine, Chiral Aminoalkylimidazoles