1123622-41-2Relevant academic research and scientific papers
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors
Thaler, Florian,Colombo, Andrea,Mai, Antonello,Amici, Raffaella,Bigogno, Chiara,Boggio, Roberto,Cappa, Anna,Carrara, Simone,Cataudella, Tiziana,Fusar, Fulvia,Gianti, Eleonora,Di Ventimiglia, Samuele Joppolo,Moroni, Maurizio,Munari, Davide,Pain, Gilles,Regalia, Nickolas,Sartori, Luca,Vultaggio, Stefania,Dondio, Giulio,Gagliardi, Stefania,Minucci, Saverio,Mercurio, Ciro,Varasi, Mario
experimental part, p. 822 - 839 (2010/07/05)
The histone deacetylases (HDACs) are able to regulate gene expression, and histone deacetylase inhibitors (HDACi) emerged as a new class of agents in the treatment of cancer as well as other human disorders such as neurodegenerative diseases. In the prese
A new class of histone deacetylase inhibitors
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, (2009/04/23)
This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: Q is a bond, CH2, NR5 or oxygen, X is CH or nitrogen, Y is a bond, CH2, oxygen or NR6, Z is CH or nit
