1123725-60-9Relevant academic research and scientific papers
Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides
Tian, Zhuang,Xu, Jiaojiao,Liu, Bingxin,Tan, Qitao,Xu, Bin
supporting information, p. 2603 - 2606 (2018/05/22)
An efficient, copper-catalyzed [3+1+1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily available nitrones and α-acidic isocyanides. The given approach features a new mo
Oligosubstituted pyrroles directly from substituted methyl isocyanides and acetylenes
Lygin, Alexander V.,Larionov, Oleg V.,Korotkov, Vadim S.,De Meijere, Armin
supporting information; experimental part, p. 227 - 236 (2009/06/20)
The formal cycloaddition of α-metallated methyl isocyanides 1 onto the triple bond of electron-deficient acetylenes 2 represents a direct and convenient approach to oligosubstituted pyrroles 3. The scope and limitations of this reaction (24 examples, 2597 % yield) are reported along with an optimization of the reaction conditions and a rationalization of the mechanism. In addition, a related newly developed CuI-mediated synthesis of 2,3-disubstituted pyrroles by the reaction of copper acetylides derived from unactivated terminal alkynes with substituted methyl isocyanides is described (11 examples, 5-88% yield).
