1123741-67-2Relevant academic research and scientific papers
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays
Jones, Lyn H.,Allan, Gill,Barba, Oscar,Burt, Catherine,Corbau, Romuald,Dupont, Thomas,Kn?chel, Thorsten,Irving, Steve,Middleton, Donald S.,Mowbray, Charles E.,Perros, Manos,Ringrose, Heather,Swain, Nigel A.,Webster, Robert,Westby, Mike,Phillips, Chris
supporting information; experimental part, p. 1219 - 1223 (2010/01/07)
A major problem associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of HIV is their lack of resilience to mutations in the reverse transcriptase (RT) enzyme. Using structural overlays of the known inhibitors efaviren
