7364-25-2Relevant articles and documents
FERROPORTIN INHIBITORS AND METHODS OF USE
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Paragraph 0447; 0448, (2020/07/07)
The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
Method for preparing 1-benzyl-3-hydroxy-1H-3-indazole sodium salt
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Paragraph 0007; 0023; 0024, (2017/08/31)
The invention relates to a method for preparing 1-benzyl-3-hydroxy-1H-3-indazole sodium salt. The method is characterized in that o-aminobenzoic acid, concentrated hydrochloric acid, a NaNO2 solution and solid Na2SO3 are taken as starting raw materials, a proper amount of a NaOH solution and a proper amount of benzyl chloride are added, and 1-benzyl-3-hydroxy-1H-3-indazole sodium salt is obtained through multi-step reaction filtering dehydration. The method is easily accessible in raw material, mild in reaction condition, low in cost and suitable for factory large-scale production.
Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents
Shen, Hong,Gou, Shaohua,Shen, Jianping,Zhu, Yanqin,Zhang, Yindi,Chen, Xuetai
scheme or table, p. 2115 - 2118 (2010/06/19)
Novel bendazac analogues and their salts have been designed and prepared. The resulting compounds (13c-d, 15c, 17c) showed very good aqueous solubility (>100 mg/mL). An in vitro assay showed that most of the resulting compounds had potent protective activ
