112378-39-9

Basic information

• Product Name: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione
• Synonyms: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione
• CAS NO: 112378-39-9
• Molecular Weight: 293.233
• Mol File: 112378-39-9.mol

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione(112378-39-9)
• EPA Substance Registry System: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione(112378-39-9)

Safety Data

• Hazardous Substances Data: 112378-39-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione is used as a key intermediate in the synthesis of complex organic molecules. Its unique structure allows for a variety of chemical reactions, making it a valuable component in the preparation of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Production:
As an intermediate, 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione plays a crucial role in the manufacturing process of certain drugs. Its presence in the synthesis pathway can lead to the development of new medications with improved efficacy and reduced side effects.
Used in Agrochemical Production:
Similar to its pharmaceutical applications, 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione is also utilized in the production of agrochemicals. Its versatility in chemical reactions enables the creation of new compounds that can be used in agriculture to protect crops from pests and diseases.
Used in Antimicrobial Applications:
2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione exhibits antimicrobial properties, making it a potential candidate for use in the development of new antimicrobial agents. These agents can be used in various industries, such as healthcare and food preservation, to combat the growth of harmful microorganisms.
Used in Anti-inflammatory Applications:
Due to its anti-inflammatory properties, 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione can be employed in the development of new anti-inflammatory drugs. These drugs can be used to treat various inflammatory conditions, providing relief and improving the quality of life for patients suffering from such ailments.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 112378-65-1 3-tert-Butyl-6-(4-nitro-phenyl)-2-phenyl-2,3-dihydro-[1,3]oxazin-4-one 
• 112378-56-0 3-tert-Butyl-5-(4-nitro-benzoyl)-2-phenyl-[1,3]oxazinane-4,6-dione 
• 112378-66-2 6-(4-Nitro-phenyl)-2,3-diphenyl-2,3-dihydro-[1,3]oxazin-4-one 
• 112378-57-1 5-(4-Nitro-benzoyl)-2,3-diphenyl-[1,3]oxazinane-4,6-dione 
• 59156-55-7 methyl 3-(4-nitrophenyl)-3-oxopropanoate 
• 13051-16-6 ethyl 2-methyl-3-(4-nitrophenyl)-3-oxopropanoate 
• 1284376-94-8 C₁₁H₁₁NO₅ 
• 42075-29-6 4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid 
• 838-57-3 ethyl 4-nitrobenzoylacetate 

Relevant articles and documents

Discovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents

A series of 4-aryl-thieno[1,4]diazepin-2-one were synthesized and evaluated for their antiproliferative activities against the A375P melanoma and U937 hematopoietic cell lines. Several compounds showed very potent antiproliferative activities toward both cell lines and the activities were better than that of sorafenib, the reference standard. Derivatives were made as amide (8a–8i, 9a–9m) and urea (10a–10d, 11a–11d) with diverse hydrophobic moieties. One of the most potent inhibitor 10d, 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno [3,4-b][1,4]diazepin-4-yl)phenyl)urea was found to be very potent inhibitor of multi-protein kinases including FMS kinase (IC50 = 3.73 nM) and is a promising candidate for further development in therapeutics for cancer.

THIENODIAZEPINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to novel thienodiazepine derivatives or pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the same. The thienodiazepine derivatives or pharmaceutically acceptable salts thereof exhibit selective inhibition activities against protein kinases such as c-Kit, FLT3, FMS, LYN, RAF1, VEGFR3, PDGFRa, PDGFRb, RET, etc., and thus can be used as a pharmaceutical composition for prevention or treatment of abnormal cell growth diseases.

A 3-methyl-4-oxo-4 - (P-amino) phenyl-butyric acid

The invention discloses a preparation method of a levosimendan key intermediate 3-methyl-4-oxo-4-(p-amino)phenylbutyric acid, which comprises six reaction steps disclosed in the specification. The method has the advantages of novel technological design, accessible raw materials, environment-friendly reaction conditions, no need of virulent chemicals, high yield of each reaction step, high total yield and safe and simple operation, and is suitable for industrial production.

Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells

Recently, we have reported the syntheses and antiproliferative activities of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl amide derivatives on melanoma cells. As a continuous work for antiproliferative agents in melanoma, here we report the synthesis of conformationally rigid analogs, phenyl-6,8- dihydropyrazolo[3,4-b][1,4]diazepin-7(1H)-one derivatives 7a-g, 8a-o and their antiproliferative activities against A375P melanoma cell line and U937 hematopoietic cell line. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard. Among them, N-(3-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl) -4-chloro-3-(trifluoro methyl)benzamide-amino-1-(4-methoxybenzyl)-1H-pyrazol-4- yl)-5-(3-(4-chloro-3-(trifluoromethyl) phenyl) ureido)-2-methylbenzamide (7b) exhibited potent activities (GI50 = 0.43 μM and 0.06 μM) on both cell lines. It has been further confirmed to be a potent and selective Raf kinases inhibitor and also mild inhibitor of PI3Kα.

Microwave assisted rapid and efficient synthesis of aryl methyl ketones and β-keto esters using Meldrum's acid

Microwave mediated rapid and efficient synthesis of aryl methyl ketones and β-keto esters from acyl Meldrum's acid by hydrolysis and alcoholysis, respectively, has been reported.

1,3-Oxazines and Related Compounds. XIII. Reaction of Acyl Meldrum's Acids with Schiff Bases Giving 2,3-Disubstituted 5-Acyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-4,6-diones and 2,3,6-Trisubstituted 2,3-Dihydro-1,3-oxazin-4-ones

The reaction of Schiff bases (2) with various acyl Meldrum's acids (1) were investigated.Refluxing of 1 and 2 in benzene caused an exchange reaction of the acetone moiety of 1 with the Schiff base moiety through the intermediate acylketenes 11 formed in s