1124-16-9

Usage

Uses

Used in Pharmaceutical Research and Drug Discovery:
2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE is used as a chemical compound in pharmaceutical research and drug discovery for its potential therapeutic applications in treating various diseases.
Used in Cancer Treatment:
In the Pharmaceutical Industry, 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE is used as a potential therapeutic agent for the treatment of cancer, due to its unique structure and biological activities.
Used in Inflammation Treatment:
In the Pharmaceutical Industry, 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE is used as a potential therapeutic agent for the treatment of inflammation, leveraging its biological properties.
Used in Neurological Disorders Treatment:
In the Pharmaceutical Industry, 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE is used as a potential therapeutic agent for the treatment of neurological disorders, given its promising effects on the nervous system.
Used in Agricultural Applications:
2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE may be used in agricultural applications, potentially contributing to crop protection or enhancement, although specific uses are not detailed in the provided materials.
Used in Industrial Applications:
2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE may also have potential uses in industrial applications, possibly in the synthesis of other organic compounds or as a component in various chemical processes, although the exact applications are not specified in the provided materials.

InChI:InChI=1/C7H13N3/c1-5(2)10-7(8)4-6(3)9-10/h4-5H,8H2,1-3H3

Upstream product

• 2257-52-5 N-isopropylhydrazine 
• 2469-99-0 Cyanoaceton 
• 1118-61-2 3-Aminocrotononitrile 
• 70629-60-6 isopropylhydrazine hydrochloride 

Downstream Products

• 77696-55-0 5-amino-4'-bromo-3,3'-dimethyl-4,5'-azobis-1-phenyl-1'-isopropyl-pyrazole 
• 1174844-27-9 C₁₃H₁₇N₃O₃ 
• 1354821-83-2 6-[4-(acetylamino)phenyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide 
• 1354822-21-1 6-chloro-3-methyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 886502-06-3 6-cyclopropyl-3-methyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 1224887-82-4 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)a mino]benzonitrile 
• 1224888-11-2 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-3-fluorobenzonitrile 
• 1224888-13-4 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-4-fluorobenzoic acid 
• 1224888-09-8 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-5-fluorobenzonitrile 
• 1224888-06-5 5-chloro-2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]benzonitrile 
• 1224888-04-3 4-chloro-2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]benzoic acid 
• 1224887-10-8 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide 
• 78831-10-4 6-(2-hydroxyphenyl)-3-methyl-1-(1-methylethyl)-5-nitropyrazolo<3,4-b>pyridine 
• 78831-28-4 1-isopropyl-3-methyl-5-(2-hydroxybenzoyl)-1H-pyrazolo<3,4-b>pyridine 

Relevant academic research and scientific papers

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

The G protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiological processes and as potential targets for numerous indications. Previously reported urea containing molecules as GIRK1/2 preferring activators have had significant pharmacokinetic (PK) liabilities. Here we report a novel series of 1H-pyrazolo-5-yl-2-phenylacetamides in an effort to improve upon the PK properties. This series of compounds display nanomolar potency as GIRK1/2 activators with improved brain distribution (rodent Kp > 0.6).

AZAINDAZOLES

Herein are disclosed azaindazoles of formula (I), (I), where the various groups are defined herein, and which are useful for treating cancer.

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure-activity relationships and the process of optimisation of an initial HTS hit are also described.