1124-16-9

Basic information

• Product Name: 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE
• Synonyms: Pyrazole, 5-amino-1-isopropyl-3-methyl-;-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE;3-Amino-2-isopropyl-5-methyl-2H-pyrazole;AKOS B024297;1-ISOPROPYL-3-METHYL-1H-PYRAZOL-5-AMINE;2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE;CHEMBRDG-BB 4013082;ART-CHEM-BB B024297
• CAS NO: 1124-16-9
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.2
• EINECS: 1533716-785-6
• Mol File: 1124-16-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 110-112℃
• Boiling Point: 245.4 °C at 760 mmHg
• Flash Point: 102.2 °C
• Appearance: /Solid
• Density: 1.1 g/cm³
• Vapor Pressure: 0.0287mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.68±0.10(Predicted)
• CAS DataBase Reference: 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE(1124-16-9)
• EPA Substance Registry System: 2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE(1124-16-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• RTECS: UQ5778000
• HazardClass: IRRITANT
• Hazardous Substances Data: 1124-16-9(Hazardous Substances Data)

Usage

General Description

2-ISOPROPYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE, also known as IMPYAM, is a chemical compound with the molecular formula C8H15N3. It is a pyrazole derivative that is commonly used in pharmaceutical research and drug discovery. IMPYAM has been studied for its potential therapeutic applications in the treatment of various diseases, including cancer, inflammation, and neurological disorders. Its unique structure and biological activities make it a promising candidate for the development of novel pharmaceutical agents. IMPYAM may also have potential uses in agricultural and industrial applications, as well as in the synthesis of other organic compounds. Overall, this chemical shows promise for various scientific and medical purposes and continues to be a subject of research and development.

InChI:InChI=1/C7H13N3/c1-5(2)10-7(8)4-6(3)9-10/h4-5H,8H2,1-3H3

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 70629-60-6 isopropylhydrazine hydrochloride 
• 2257-52-5 N-isopropylhydrazine 
• 2469-99-0 Cyanoaceton 

Downstream Products

• 1224887-10-8 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide 
• 1224888-04-3 4-chloro-2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]benzoic acid 
• 1224888-06-5 5-chloro-2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]benzonitrile 
• 1224888-09-8 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-5-fluorobenzonitrile 
• 1224888-13-4 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-4-fluorobenzoic acid 
• 1224888-11-2 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-3-fluorobenzonitrile 
• 1224887-82-4 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)a mino]benzonitrile 
• 1174844-27-9 C₁₃H₁₇N₃O₃ 
• 1354821-83-2 6-[4-(acetylamino)phenyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide 
• 1354822-21-1 6-chloro-3-methyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 886502-06-3 6-cyclopropyl-3-methyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 78831-10-4 6-(2-hydroxyphenyl)-3-methyl-1-(1-methylethyl)-5-nitropyrazolo<3,4-b>pyridine 
• 78831-28-4 1-isopropyl-3-methyl-5-(2-hydroxybenzoyl)-1H-pyrazolo<3,4-b>pyridine 
• 77696-55-0 5-amino-4'-bromo-3,3'-dimethyl-4,5'-azobis-1-phenyl-1'-isopropyl-pyrazole 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

AZAINDAZOLES

Herein are disclosed azaindazoles of formula (I), (I), where the various groups are defined herein, and which are useful for treating cancer.