2257-52-5

Basic information

• Product Name: 1-ISOPROPYLHYDRAZINE
• Synonyms: isopropylhydrazine(SALTDATA: HCl);Hydrazine, (1-Methylethyl)-;Hydrazine,(1-Methylethyl)- (9CI);Isopropylhydrazine HCL.;(1-methylethyl)Hydrazine;N-isopropylhydrazine
• CAS NO: 2257-52-5
• Molecular Formula: C₃H₁₀N₂
• Molecular Weight: 74.13
• EINECS: 604-604-1
• Mol File: 2257-52-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 111-113 °C
• Boiling Point: 120.1°Cat760mmHg
• Flash Point: 24.8°C
• Appearance: /
• Density: g/cm³
• PKA: 8.34±0.70(Predicted)
• CAS DataBase Reference: 1-ISOPROPYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOPROPYLHYDRAZINE(2257-52-5)
• EPA Substance Registry System: 1-ISOPROPYLHYDRAZINE(2257-52-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2257-52-5(Hazardous Substances Data)

Usage

Uses

Isopropyl-hydrazine can be used for water corrosion prevention.

Synthetic route

isopropyl alcohol (67-63-0) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride; hydrazine hydrate In water at 30 - 115℃; under 4500.45 Torr; for 2.5h; pH=6.5 - 7; Temperature; Pressure; Large scale;	95.7%
With hydrazine hydrate at 80 - 130℃; for 6h; Temperature;	351.8 g
With hydrazine hydrate; zinc aluminate at 80 - 130℃; for 8h; Temperature; Sealed tube;	352.1 g

acetone hydrazone (5281-20-9) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride; platinum Hydrogenation;

acetone isopropylhydrazone (7423-01-0) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride Hydrogenation;
With water Hydrogenation;

1-acetyl-2-isopropylhydrazine (4466-50-6) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With sodium hydroxide

1-isopropyl semicarbazide (14869-57-9) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With sulfuric acid

2-isopropylhydrazine-1-carboxylic acid ethyl ester (6637-65-6) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With 30percent NaOH In water for 12h; Heating;
With sodium hydroxide

isopropylamine (75-31-0) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With chloroamine

acetone (67-64-1) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride; hydrazine hydrate; platinum Hydrogenation;

N-isopropylsydnone (6939-17-9) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride

C15H19N2OP (70629-52-6) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride Heating;

isopropyl bromide (75-26-3) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrazine hydrate
With sodium hydroxide; hydrazine In water at 80℃; for 14h;

benzophenone-2-propylhydrazone (343222-47-9) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride In ethanol at 25℃; for 15h; Yield given;

2.2'-azopropane → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrogenchloride
With hydrogenchloride; benzene
With hydrogenchloride; diethyl ether

isopropylamine (75-31-0) + O-sulfo-hydroxylamine → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With potassium hydroxide; water

acetone isopropylhydrazone (7423-01-0) + water (7732-18-5) → N-isopropylhydrazine (2257-52-5)

hydrogenchloride (7647-01-0) + acetone isopropylhydrazone (7423-01-0) + acetone (67-64-1) → N-isopropylhydrazine (2257-52-5)

hydrogenchloride (7647-01-0) + acetone hydrazone (5281-20-9) + platinum → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
Hydrogenation;

diethyl ether (60-29-7) + azobisisopropane (15464-00-3) + HCl → N-isopropylhydrazine (2257-52-5) + acetone (67-64-1)

ethanol (64-17-5) + azobisisopropane (15464-00-3) + HCl → N-isopropylhydrazine (2257-52-5) + acetone (67-64-1)

azobisisopropane (15464-00-3) + hydrochloric acid → N-isopropylhydrazine (2257-52-5) + acetone (67-64-1)

ethanol (64-17-5) + isopropyl chloride (75-29-6) + hydrazine (302-01-2) → N-isopropylhydrazine (2257-52-5) + N.N-diisopropyl-hydrazine + N.N'-diisopropyl-hydrazine

Conditions	Yield
at 150℃;

1-iodo-propane (107-08-4) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With hydrazine hydrate

isopropylhydrazine hydrochloride (70629-60-6, 73941-11-4, 16726-41-3) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;

tert-butyl 2-(isopropyl)hydrazinecarboxylate (16689-35-3) → N-isopropylhydrazine (2257-52-5)

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;

N-isopropylhydrazine (2257-52-5) + o-carboxybenzaldehyde (119-67-5) → 2-isopropyl-2H-phthalazin-1-one (63536-32-3)

Conditions	Yield
at 70℃; for 1h; Large scale;	98.76%

N-isopropylhydrazine (2257-52-5) + 2-Chlorocyclohexanone (822-87-7) → 1-isopropylazocyclohexene (873311-06-9)

Conditions	Yield
With potassium carbonate In dichloromethane at -10 - 20℃;	95%

N-isopropylhydrazine (2257-52-5) + 2-(α-aminobenzylidene)indane-1,3-dione (85301-69-5) → 1-isopropyl-3-phenyl-1H-indeno[1,2-c]pyrazol-4-one (69545-78-4)

Conditions	Yield
In ethanol for 25h; Heating;	93%

N-isopropylhydrazine (2257-52-5) + 4-Methoxybenzenethiol (696-63-9) → 1-methoxy-4-<(1-methylethyl)thio>-benzene (7205-61-0)

Conditions	Yield
With C26H36N2O6; oxygen; cobalt(II) chloride; potassium hydroxide at 40℃; under 2250.23 Torr; for 22h;	91%
With copper(II) nitrate trihydrate; 4,7-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,10-phenanthroline; oxygen; caesium carbonate In water at 100℃; under 760.051 Torr; for 12h; Schlenk technique; Green chemistry; chemoselective reaction;	85%

N-isopropylhydrazine (2257-52-5) + pentanonitrile (110-59-8) → 3,5-dibutyl-1-isopropyl-1H-1,2,4-triazole

Conditions	Yield
With potassium tert-butylate In 1,4-dioxane at 120℃; for 0.166667h; Glovebox; Sealed tube;	91%

N-isopropylhydrazine (2257-52-5) + methyl heptafluorobutyrate (356-24-1) → 2,2,3,3,4,4,4-Heptafluoro-butyric acid N'-isopropyl-hydrazide

Conditions	Yield
With hydrazine In methanol	89%

N-isopropylhydrazine (2257-52-5) + C14H17NO → 1-isopropyl-4-(4-isopropylphenyl)-3,5-dimethyl-1H-pyrazole

Conditions	Yield
With hydrogenchloride; tricarbonyl(cycloheptatriene)molybdenum(0) In tetrahydrofuran; water at 70℃; for 16h; Sealed tube;	89%

N-isopropylhydrazine (2257-52-5) + methyl 3,4,5-trimethoxyphenoxyacetate (24789-74-0) → 1-(3,4,5-Trimethoxyphenoxyacetyl)-2-(2-propyl)hydrazine (116876-88-1)

Conditions	Yield
With sodium methylate at 100 - 120℃; for 12h;	88%

N-isopropylhydrazine (2257-52-5) + ethyl 7-iodo-3-oxoheptanoate (153851-18-4) → C10H16N2O

Conditions	Yield
With sodium acetate In acetic acid at 110℃; for 12h;	88%

N-isopropylhydrazine (2257-52-5) + ethyl 2-methyl-4,4,4-trifluoroacetoacetate (344-00-3) → 5-hydroxy-4-methyl-1-iso-propyl-3-trifluoromethyl-1H-pyrazole

Conditions	Yield
Stage #1: N-isopropylhydrazine; ethyl 2-methyl-4,4,4-trifluoroacetoacetate In ethanol at 0 - 20℃; for 0.5h; Stage #2: With hydrogenchloride In water for 48h; Heating / reflux;	87%

N-isopropylhydrazine (2257-52-5) + 4-Hydroxy-4-methyl-2-pentanone (123-42-2) → Diacetone alcohol monoisopropylhydrazone (84646-09-3)

Conditions	Yield
In benzene 1) mixing below 15 deg C, 2) room temp., 1 h.;	86%

N-isopropylhydrazine (2257-52-5) + 2-(1'-Amino-2',2'-dimethyl)propylidenyl-1,3-indandione (82501-35-7) → 3-tert-butyl-1-isopropyl-1H-indeno[1,2-c]pyrazol-4-one (68946-15-6)

Conditions	Yield
In ethanol for 3h; Heating;	86%

N-isopropylhydrazine (2257-52-5) + acetophenone (98-86-2) → N-Isopropyl-N'-[1-phenyl-eth-(Z)-ylidene]-hydrazine

Conditions	Yield
In diethyl ether Heating;	86%

N-isopropylhydrazine (2257-52-5) + 1,3-diphenylpropanedione (120-46-7) → 1-isopropyl-3,5-diphenyl-1H-pyrazole (1268869-16-4)

Conditions	Yield
In ethanol; water for 24h; Reflux;	84%

N-isopropylhydrazine (2257-52-5) + salicylaldehyde (90-02-8) → Salicylaldehyde monoisopropyl hydrazone (82046-37-5)

Conditions	Yield
In benzene 1) mixing below 15 deg C, 2) room temp., 1 h.;	83%

N-isopropylhydrazine (2257-52-5) + 3,3-dimethyl-2,4-pentanedione (3142-58-3) → 1-isopropyl-5-methylene-3,4,4-trimethyl-2-pyrazoline (107535-59-1)

Conditions	Yield
With trifluoroacetic acid In benzene Heating; removal of water;	82%
	80%
In diethyl ether for 4h;	18%

N-isopropylhydrazine (2257-52-5) + trifluoroacetic acid-methyl ester (431-47-0) → Trifluoro-acetic acid N'-isopropyl-hydrazide

Conditions	Yield
With hydrazine In methanol	82%

N-isopropylhydrazine (2257-52-5) + 2-bromophenyl methyl ketone (2142-69-0) → N-[1-(2-Bromo-phenyl)-eth-(Z)-ylidene]-N'-isopropyl-hydrazine (128364-50-1, 128364-51-2)

Conditions	Yield
In diethyl ether Heating;	82%

N-isopropylhydrazine (2257-52-5) + (E)-2-(1-methoxy-3-phenylallyldiene)malononitrile → (E)-5-amino-1-isopropyl-3-styryl-1H-pyrazole-4-carbonitrile

Conditions	Yield
With triethylamine In ethanol at 0 - 20℃; for 0.5h;	82%

N-isopropylhydrazine (2257-52-5) + 3,3-dimethyl-2,4-pentanedione (3142-58-3) → 4-(Isopropyl-hydrazono)-3,3-dimethyl-pentan-2-one (118487-26-6) + 1-isopropyl-5-methylene-3,4,4-trimethyl-2-pyrazoline (107535-59-1)

Conditions	Yield
In diethyl ether for 4h; distillation of reaction mixture under high vacuum;	A 80% B n/a

N-isopropylhydrazine (2257-52-5) + ethyl 4-(2-iodoethoxy)-3-oxobutanoate (221446-38-4) → C9H14N2O2

Conditions	Yield
With sodium acetate In acetic acid at 110℃; for 12h;	79%

N-isopropylhydrazine (2257-52-5) + perfluoropropionic acid methyl ester (378-75-6) → 2,2,3,3,3-Pentafluoro-propionic acid N'-isopropyl-hydrazide

Conditions	Yield
With hydrazine In methanol	77%

N-isopropylhydrazine (2257-52-5) + 5-[(Z)-1-(4-fluorophenyl)methylidene]-2-(5-3-[5-[(Z)-1-(4-fluorophenyl)methylidene]-3-(4-methylphenyl)-4-oxo-1-3-thiazolan-2-yl]-4-methoxybenzyl-2-methoxyphenyl)-3-(4-methylphenyl)-1,3-thiazolan-4-one (1184912-67-1) → bis-[4-methoxy-3-[3-(4-fluorophenyl)-2-isopropyl-6-(4-methylphenyl)-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d][1,3]thiazol-5-yl]phenyl]methane (1184912-78-4)

Conditions	Yield
With sodium acetate In acetic acid for 7h; Reflux;	76%

N-isopropylhydrazine (2257-52-5) + lithium (Z)-1-ethoxy-4-(4-isopropylphenyl)-1,4-dioxobut-2-en-2-olate → ethyl 1-isopropyl-5-(4-isopropylphenyl)-1H-pyrazole-3-carboxylate

Conditions	Yield
In ethanol at 90℃; for 5h;	76%

N-isopropylhydrazine (2257-52-5) + dibenzylideneacetone (35225-79-7) → (E)-1-(2-isopropyl-3,4,6-triphenyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-3-phenylpropen-2-one

Conditions	Yield
In ethanol for 3h; Heating;	73%

N-isopropylhydrazine (2257-52-5) + methyl perfluoroheptanoate (14312-89-1) → 2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptanoic acid N'-isopropyl-hydrazide

Conditions	Yield
With hydrazine In methanol	72%

N-isopropylhydrazine (2257-52-5) + 3-phenyl-N,N-dipropylprop-2-yn-1-amine (153396-18-0) → 5-phenyl-1-(propan-2-yl)-1H-pyrazole + 3-phenyl-1-(propan-2-yl)-1H-pyrazole

Conditions	Yield
Stage #1: N,N-dipropyl-3-phenylprop-2-yn-1-amine With peroxyacetic acid In ethanol at 85℃; for 1h; Stage #2: N-isopropylhydrazine In ethanol at 85℃; for 0.5h;	A 19% B 72%

N-isopropylhydrazine (2257-52-5) + 5-[(Z)-1-(4-fluorophenyl)methylidene]-2-(5-3-[5-[(Z)-1-(4-fluorophenyl)methylidene]-3-(4-nitrophenyl)-4-oxo-1,3-thiazolan-2-yl]-4-methoxybenzyl-2-methoxyphenyl)-3-(4-nitrophenyl)-1,3-thiazolan-4-one (1184912-70-6) → bis-[4-methoxy-3-[3-(4-fluorophenyl)-2-isopropyl-6-(4-nitrophenyl)-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d][1,3]thiazol-5-yl]phenyl]methane (1184912-91-1)

Conditions	Yield
With sodium acetate In acetic acid for 7h; Reflux;	71%

N-isopropylhydrazine (2257-52-5) + 2,4-dichloro-N-(2,6-dimethylphenyl)pyrimidin-5-carboxamide (835633-82-4) → 2-chloro-N-(2,6-dimethylphenyl)-4-(1-isopropylhydrazinyl)pyrimidin-5-carboxamide

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 2h;	71%

Upstream product

• 7423-01-0 acetone isopropylhydrazone 
• 14869-57-9 1-isopropyl semicarbazide 
• 6637-65-6 2-isopropylhydrazine-1-carboxylic acid ethyl ester 
• 75-31-0 isopropylamine 
• 67-64-1 acetone 
• 75-26-3 isopropyl bromide 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 5281-20-9 acetone hydrazone 
• 60-29-7 diethyl ether 
• 15464-00-3 azobisisopropane 
• 64-17-5 ethanol 
• 75-29-6 isopropyl chloride 
• 302-01-2 hydrazine 

Downstream Products

• 21254-23-9 5-Amino-4-cyan-1-isopropyl-pyrazol 
• 1759-24-6 5-amino-1-isopropyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 3734-29-0 N-(Phenylisopropyl)-N'-isopropylhydrazin 
• 35787-02-1 N,N'-dibenzoyl-N-isopropyl-hydrazine 
• 21076-38-0 1-isopropyl-4-phenyl thiosemicarbazide 
• 89937-50-8 α-(2-Isopropyl-hydrazino)-propionsaeure 
• 56360-74-8 C₂₁H₃₀N₆O₂ 
• 51126-18-2 Thiobenzoesaeure-(N¹-isopropyl-hydrazid) 
• 56335-83-2 1-isopropyl-2-thiobenzoylhydrazine 
• 96715-30-9 1-isopropyl-2-phenylthioacetylhydrazine 
• 82046-37-5 Salicylaldehyde monoisopropyl hydrazone 
• 92058-40-7 N-Isopropyl-N'-phenethyl-hydrazin 
• 109953-69-7 benzyl-2-isopropylcarbazate 
• 58605-87-1 1-cyano-1-isopropylhydrazine 

Relevant articles and documents

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Preparation method for isopropyl hydrazine

The invention provides a preparation method for isopropyl hydrazine. The method comprises the step: under the protection of inert gases, carrying out an alkylation reaction on isopropanol and hydrazine hydrate under the effect of a catalyst at a certain temperature, to generate the isopropyl hydrazine. After the reaction ends, an organic phase of isopropyl hydrazine is separated from a water phase, and then the organic phase is rectified to obtain an isopropyl hydrazine finished product, and the catalyst used for the reaction is HD-8 porous highly acidic cation exchange resin. Compared with the prior art, the isopropyl hydrazine is synthesized in a one-step method by taking isopropanol and hydrazine hydrate as raw materials, and the method is few in processing steps, simple in post-treatment, little in reaction dangerousness, high in yield, low in production cost and little in waste emission and is an environment-friendly production technology.

A synthesis method of the isopropyl group jing

The invention provides a method for synthesizing isopropyl group jing, the method is characterized in that the inert gas under the protection of the isopropyl alcohol and hydrazine hydrate under the action of catalyst and under a certain temperature for carrying out the alkylation reaction, generating isopropyl group jing, after the reaction of the isopropyl group jing will contain the organic phase separated from the aqueous phase, then the organic phase and get the isopropyl group jing the finished product, the reaction catalyst is sodium hexametaphosphate. Compared with the prior art, the present invention in order to isopropanol and hydrazine as raw material, one-step synthesis of isopropyl group jing, its few reaction steps, after treatment is simple, the small risk of reaction, high yield, low production cost, waste is discharged little, is an environment-friendly production process.