112407-98-4Relevant academic research and scientific papers
SYNTHESIS OF PEPTIDES WITH α,β-DEHYDROAMINO ACIDS. PART VIII. A CONVENIENT SYNTHESIS OF N-PROTECTED α,β-DEHYDROPEPTIDE METHYL ESTERS
Kubica, Z.,Rzeszotarska, B.,Smelka, L.
, p. 1263 - 1268 (2007/10/02)
Based on results of the examination of the action of diazomethane on Z-Gly-ΔAbu and/or Z-Gly-ΔAbu-OMe (Table 1) a series of twelve model N-protected α,β-dehydrodipeptide methyl esters 1-12 was obtained.Yields and purity of isolated products amounted to 80-94percent and 98-100percent, respectively (Table 2).
Dehydrooligopeptides. VII. Convenient Synthesis of Various Dehydrodi- and tripeptide Esters by Using N-Carboxy α-Dehydroamino Acid Anhydride
Shin, Chuung-gi,Yonezawa, Yasuchika,Ikeda, Masahiro
, p. 3573 - 3579 (2007/10/02)
The one-pot syntheses of N-protected Δ1- and Δ2-dehydrodipeptide esters by the coupling of N-carboxy α-dehydroamino acid anhydride (ΔNCA) with several kinds of C- or N-protected L-α-amino acids are described.In addition, it was found that a similar coupling of ΔNCA with both C- and N-protected α-amino acids also took place to give Δ2-dehydrotripeptide derivatives, involving eight kinds of important C-terminal segments of antrimycins and cirratiomycins.The configurational confirmation of the α-dehydroisoleucine residue of the antibiotics is also discussed.
