112428-09-8

Basic information

• Product Name: Pentanedioic acid, 2,2-dimethoxy-4-(phenylmethyl)-, dimethyl ester
• CAS NO: 112428-09-8
• Molecular Formula: C16H22O6
• Molecular Weight: 310.347
• Mol File: 112428-09-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pentanedioic acid, 2,2-dimethoxy-4-(phenylmethyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanedioic acid, 2,2-dimethoxy-4-(phenylmethyl)-, dimethyl ester(112428-09-8)
• EPA Substance Registry System: Pentanedioic acid, 2,2-dimethoxy-4-(phenylmethyl)-, dimethyl ester(112428-09-8)

Safety Data

• Hazardous Substances Data: 112428-09-8(Hazardous Substances Data)

Upstream product

• 4469-60-7 dimethyl 2,2-dimethoxypentanedioate 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Allele-Specific Chemical Rescue of Histone Demethylases Using Abiotic Cofactors

Closely related protein families evolved from common ancestral genes present a significant hurdle in developing member- and isoform-specific chemical probes, owing to their similarity in fold and function. In this piece of work, we explore an allele-specific chemical rescue strategy to activate a "dead"variant of a wildtype protein using synthetic cofactors and demonstrate its successful application to the members of the alpha-ketoglutarate (αKG)-dependent histone demethylase 4 (KDM4) family. We show that a mutation at a specific residue in the catalytic site renders the variant inactive toward the natural cosubstrate. In contrast, αKG derivatives bearing appropriate stereoelectronic features endowed the mutant with native-like demethylase activity while remaining refractory to a set of wild type dioxygenases. The orthogonal enzyme-cofactor pairs demonstrated site- and degree-specific lysine demethylation on a full-length chromosomal histone in the cellular milieu. Our work offers a strategy to modulate a specific histone demethylase by identifying and engineering a conserved phenylalanine residue, which acts as a gatekeeper in the KDM4 subfamily, to sensitize the enzyme toward a novel set of αKG derivatives. The orthogonal pairs developed herein will serve as probes to study the role of degree-specific lysine demethylation in mammalian gene expression. Furthermore, this approach to overcome active site degeneracy is expected to have general application among all human αKG-dependent dioxygenases.

Antibiotic 2-(3-oxo-2-isoxazolidinyl)-5-oxo-2-tetrahydrofuran-carboxylates

The compound represented by the formula: STR1 where R1 stands for amino or an organic residue bonded through nitrogen; R2 stands for carboxyl or a group derivable therefrom; R3, R4, R5, R6, R7 and R8 independently stand for hydrogen or an organic residue, including the case where R5 or R6 forms a chemical bond or a ring with R7 or R8 ; X stands for hydrogen, methoxy or formylamino; or a salt thereof, produceable by the present method, exhibits excellent antimicrobial activity, and is utilized as antimicrobial agents.