112440-16-1Relevant academic research and scientific papers
1,3-Dipolar cycloadditions of silicon and tin alkynes and alkenes. Regiospecific synthesis of silyl and stannylpyrazoles and pyrazolines
González-Nogal, Ana M.,Calle, Mariola,Cuadrado, Purificación,Valero, Raquel
, p. 224 - 231 (2007)
Silicon and tin 3-, 3,5-, and 3,4,5-metalated pyrazoles have been synthesized by 1,3-dipolar cycloadditions of silyl-, disilyl-, and silylstannylacetylenes with N-phenylsydnone or trimethylsilyldiazomethane. On the other hand, 1- and 2-pyrazolines monomet
Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D
Brito, Gilmar A.,Jung, Woo-Ok,Yoo, Minjin,Krische, Michael J.
supporting information, p. 18803 - 18807 (2019/11/19)
Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.
Indanol-Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization
Hashimoto, Takuya,Shimazaki, Yuto,Omatsu, Yamato,Maruoka, Keiji
supporting information, p. 7200 - 7204 (2018/06/15)
Rapid development in the last decade has rendered chiral organoiodine(I/III) catalysis a reliable methodology in asymmetric catalysis. However, due to the severely limited numbers of effective organoiodine catalysts, many reactions still give low to modes
2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER
-
Page/Page column 83, (2015/01/16)
The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.
Synthesis of enantioenriched allenes from 1,1-cyclopropanediesters
Cerat, Pascal,Gritsch, Philipp J.,Goudreau, Sebastien R.,Charette, Andre B.
supporting information; experimental part, p. 564 - 567 (2010/06/13)
[Chemical equation presented] Highly substituted alienes were obtained by the SN2′ addition of organocuprate reagents on 2-propargyl-1,1-cyclopropanediesters. This new methodology permits the synthesis of highly enantioenriched allenes as the r
Convenient access to functionalized vinylcyclopentenols from alkynyloxiranes
Wang, Letian,Maddess, Matthew L.,Lautens, Mark
, p. 1822 - 1825 (2007/10/03)
β,γ-Alkynyl aldehydes, generated in situ by treatment of alkynyloxiranes with a catalytic amount of Sc(OTf)3 or BF 3· OEt2, are effectively trapped by a variety of allyl nucleophiles to afford homopropargylic homoallylic a
Taxamycins: A new enediyne family with synthetic and biological potential
Lu,Harwig,Fallis
, p. 2253 - 2262 (2007/10/03)
The Pd(0) based synthesis of two disilyl synthons (Z-1-trimethylsilyl-6-tert-butyldiphenylsilylhex-3-ene-1,5-diyne (18) and Z-1-trimethylsilyl-6-triisopropylsilylhex-3-ene-1,5-diyne (19) and the selective removal of the trimethylsilyl group (K2
The Stereochemistry of Organometallic Compounds. XXXIV. Regioselection in the Hydroformylation of Silylalkenes
Doyle, M. Michael,Jackson, W. Roy,Perlmutter, Patrick
, p. 1907 - 1918 (2007/10/02)
The regiochemistry of hydroformylation of alkenes can be controlled by use of bulky silyl groups attached to the alkene.Use of the t-butyldiphenylsilyl group leads to almost total regiocontrol and the method has been applied to the synthesis of aldols.
