126741-69-3Relevant academic research and scientific papers
Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D
Brito, Gilmar A.,Jung, Woo-Ok,Yoo, Minjin,Krische, Michael J.
supporting information, p. 18803 - 18807 (2019/11/19)
Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.
Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide
Ohkuma, Takeshi,Kurono, Nobuhito,Sakaguchi, Yusuke,Yamauchi, Kohei,Yurino, Taiga
supporting information, p. 1517 - 1522 (2018/02/28)
Asymmetric cyanosilylation of alkynyl ketones with the catalyst systems consisting of amino acid/2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP)/ruthenium(II) complex and lithium phenoxide (Ru?Li cat.) was studied. The reaction was conducted in tert-butyl methyl ether (TBME) at ?78 °C with a substrate-to-catalyst molar ratio (S/C) as high as 2000. A series of simple and functionalized ketones was converted into the alkynyl tertiary cyanohydrin derivatives in up to 99% ee. Appropriate selection of an amino-acid ligand of the catalyst according to the substrate structure was crucially important to achieve high enantioselectivity and a wide scope of substrates. Transformation of the chiral cyanohydrin product into a functionalized lactone was also examined. (Figure presented.).
Improved method for the synthesis of β-carbonyl silyl-1,3-dithianes by the double conjugate addition of 1,3-dithiol to propargylic carbonyl compounds
Mukherjee, Sumit,Kontokosta, Dimitra,Patil, Aditi,Rallapalli, Sivakumar,Lee, Daesung
supporting information; experimental part, p. 9206 - 9209 (2010/03/02)
(Chemical Equation Presented) Base-mediated double conjugate addition of 1,3-propane dithiol to various silylated propargylic aldehydes and ketones allows for an efficient and scalable synthesis of β-carbonyl silyl-1,3-dithianes.
The Stereochemistry of Organometallic Compounds. XXXIV. Regioselection in the Hydroformylation of Silylalkenes
Doyle, M. Michael,Jackson, W. Roy,Perlmutter, Patrick
, p. 1907 - 1918 (2007/10/02)
The regiochemistry of hydroformylation of alkenes can be controlled by use of bulky silyl groups attached to the alkene.Use of the t-butyldiphenylsilyl group leads to almost total regiocontrol and the method has been applied to the synthesis of aldols.
