112463-93-1

Upstream product

• 114495-36-2 (R)-2-Methoxycarbonylamino-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 116-54-1 dichloroacetic acid methyl ester 
• 112463-92-0 [(R)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid methyl ester 
• 113089-15-9 (S)-2-methoxycarbonylamino-3-(4-methoxyphenyl)-propionic acid methyl ester 
• 598-99-2 Methyl trichloroacetate 
• 112463-92-0 [(S)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid methyl ester 

Downstream Products

• 112464-01-4 Acetic acid (3S,4R,5R)-4-hydroxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester 
• 112463-97-5 (1R,4R,5R)-4-(4-Methoxy-benzyl)-6-oxa-3-aza-bicyclo[3.1.0]hexan-2-one 
• 112487-80-6 Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester 
• 112463-95-3 (R)-3-Chloro-4-hydroxy-5-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 27958-06-1 (2R,3S,4S)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine 
• 112463-94-2 (R)-3,3-Dichloro-4-hydroxy-5-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 113158-91-1 (4R,5S)-3,3-Dichloro-4-hydroxy-5-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 113158-90-0 (4S,5S)-3,3-Dichloro-4-hydroxy-5-(4-methoxy-benzyl)-pyrrolidin-2-one 

Relevant academic research and scientific papers

A new Stereoselective Method of Synthesis of Pyrrolizidines and Indolizidines

The addition of electrogenerated dichloro(methoxycarbonyl)methyl anions to some N-(methoxycarbonyl)-α-amino aldehydes prepared from α-amino acids was found to show about 100percent diastereoselectivity.Some alkaloid type compounds containing pyrrolizidine and indolizidine skeletons were synthesized from the adducts.

Total Synthesis of (-)-Anisomycin

Antibiotic (-)-anisomycin was synthesized starting from D-tyrosine using the addition of electrogenerated dichloro-(methoxycarbonyl)methyl anion to aldehyde 2 as a key reaction.