112482-36-7Relevant articles and documents
Regioselective synthesis of fluorohydrines via SN2-type ring-opening of epoxides with TBABF-KHF2
Akiyama, Yuriko,Fukuhara, Tsuyoshi,Hara, Shoji
, p. 1530 - 1532 (2003)
We found that the ring-opening fluorination of terminal epoxides using TBABF-KHF2 proceeds with high selectivity through the SN2 mechanism. As TBABF-KHF2 is easily obtainable, is stable, and can be used in glassware, it ca
Synthesis and antiviral study of acyclic analogs of 3'-azido, 3'-amino, and 3'fluoro-3'-deoxythymidine, and HEPT analogs
Trinh,Florent,Grierson,Monneret
, p. 939 - 943 (2007/10/02)
Several new acyclonucleosides have been synthesized from racemic epichlorhydrin or epifluorhydrin. This involves epoxide opening followed by chain elongation with iodomethyl phenyl sulfide and subsequent coupling of the phenylthioacetal with thymine. Deprotection afforded the title compounds 6, (and 18, whereas introduction of a phenylthio group at C-6 led to the three HEPT analogs, 13, 19, and 24.
Regioselective conversion of O-protected glycidols to fluorohydrins catalyuzed by tetrabutylammonium dihydrogentrifluoride under solid-liquid PTC conditions
Landini, Dario,Albanese, Domenico,Penso, Michele
, p. 4163 - 4170 (2007/10/02)
A number of O-protected glycidols are regioselectively converted into the corresponding fluorohydrins FCH2CH(OH)CH2OX by reaction with catalytic amounts of Bu4N+H2F3- and a molar
