112482-49-2Relevant academic research and scientific papers
Synthesis of the 5-fluoro-4-hydroxypentyl side chain metabolites of synthetic cannabinoids 5F-APINACA and CUMYL-5F-PINACA
McKinnie, Ryan J.,Darweesh, Tasneam,Zito, Phoebe A.,Shields, Terrell J.,Trudell, Mark L.
, p. 4683 - 4689 (2019/02/01)
An efficient method for the construction of the 5-fluoro-4-hydroxypentyl side chain common to a number of synthetic cannabinoid metabolites was developed. A series of hydroxyl protecting groups was examined to assess the viability as orthogonal protecting
Regioselective Opening of Simple Epoxides with Diisopropylamine Trihydrofluoride
Muehlbacher, Manfred,Poulter, C. Dale
, p. 1026 - 1030 (2007/10/02)
Treatment of benzyl ether derivatives of simple aliphatic epoxy alcohols with diisopropylamine trihydrofluoride gave mixtures of the corresponding fluorohydrins in good yields.Steric hindrance is a major factor in determining the regioselectivity of epoxide opening, although electronic effects cannot be ignored.Electronic effects are more dominant with pyridine polyhydrofluoride.
