112489-39-1

Upstream product

• 931-94-2 1,1-dimethoxycyclopentane 
• 28140-40-1 1,4,5,6-tetra-O-benzyl-myo-inositol 
• 109575-71-5 indicoside A 
• 96533-43-6 2,3-O-cyclopentylidene-myo-inositol 
• 100-44-7 benzyl chloride 
• 201860-64-2 2-O-(4-Methoxytetrahydropyran-4-yl)-myo-inositol 
• 201860-63-1 1,3,4,5,6-Penta-O-(p-anisoyl)-myo-inositol 
• 201860-67-5 6-O-{2,7-Dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-3-O-(-)-menthoxyacetyl-2-O-(4-methoxytetrahydropyran-4-yl)-4,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-myo-inositol 
• 329327-20-0 (5aR,6S,7R,7aR,12aS,12bS)-2,2,4,4,9,9,11,11-Octaisopropyl-hexahydro-1,3,5,8,10,12-hexaoxa-2,4,9,11-tetrasila-benzo[1,2;3,4]dicycloheptene-6,7-diol 
• 329327-19-7 ((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2S,3S,4S,4aR,9aR)-3,4-dihydroxy-6,6,8,8-tetraisopropyl-2-(4-methoxy-tetrahydro-pyran-4-yloxy)-hexahydro-5,7,9-trioxa-6,8-disila-benzocyclohepten-1-yl ester 
• 329327-07-3 ((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (5aR,6S,7R,7aR,12aS,12bS)-2,2,4,4,9,9,11,11-octaisopropyl-7-(4-methoxy-tetrahydro-pyran-4-yloxy)-hexahydro-1,3,5,8,10,12-hexaoxa-2,4,9,11-tetrasila-benzo[1,2;3,4]dicyclohepten-6-yl ester 
• 329327-17-5 C₅₂H₅₂O₁₈ 
• 26276-99-3 rac-1,4,5,6-tetra-O-benzyl-myo-inositol 

Downstream Products

• 112489-41-5 rac. 2,3-O-cyclopentylidine-6-O-(2,7-dibromo-9-phenylxanthen-9-yl)-myo-inositol 
• 112489-43-7 rac. hexakis(2-cyanoethyl) 2,3-O-cyclopentylidine-6-O-(2,7-dibromo-9-phenylxanthen-9-yl)-myo-inositol 1,4,5-triphosphate 
• 112489-44-8 C₃₀H₃₁Br₂O₁₆P₃ 
• 112489-41-5 2,3-O-cyclopentylidine-6-O-(2,7-dibromo-9-phenylxanthen-9-yl)-D-myo-inositol 
• 112489-43-7 hexakis(2-cyanoethyl) 2,3-O-cyclopentylidine-6-O-(2,7-dibromo-9-phenylxanthen-9-yl)-D-myo-inositol 1,4,5-triphosphate 
• 112489-44-8 C₃₀H₃₁Br₂O₁₆P₃ 
• 28140-40-1 1,4,5,6-tetra-O-benzyl-myo-inositol 

Relevant academic research and scientific papers

Synthesis of naturally occurring phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and its diastereoisomers

The chemical synthesis of naturally occurring phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3] and its diastereoisomers was discussed. In the first stage, the preparation of the required enantiomeric 1,2-di-O-acylglycerol derivatives was done. The second stage involved the preparation of suitably protected enantiomeric myo-inositol 1-phosphates. The glycerol and inositol building blocks were coupled together and the 3-, 4- and 5-hydroxy functions of the inositol residues in the coupled products were phosphorylated. Finally, the protecting groups were removed to give PtdIns(3,4,5)P3 and its diastereoisomers.

SYNTHESIS OF D-myo-INOSYTOL 1,4,5-TRIPHOSPHATE

The conversion of myo-inositol into the ammonium salts both of racemic and enantiomerically pure D-myo-inositol 1,4,5-triphosphate (6) is described.The n.m.r. spectroscopic properties and biological activity of synthetic and naturally-isolated (6) are virtually identical.