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1,3,5-Trimethyl-4-nitro-1H-pyrazole, commonly known as Pirodustat, is a pyrazole-based chemical compound that functions as a potent inhibitor of the enzyme prolyl hydroxylase. This enzyme plays a crucial role in the regulation of erythropoietin, a hormone that is integral to the stimulation of red blood cell production. Pirodustat's ability to modulate erythropoietin levels positions it as a significant pharmaceutical candidate for the treatment of various conditions related to anemia and tissue oxygenation.

1125-30-0

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1125-30-0 Usage

Uses

Used in Pharmaceutical Research:
1,3,5-Trimethyl-4-nitro-1H-pyrazole is used as a research compound for the development of new treatments targeting anemia and other related conditions. Its mechanism of action involves the inhibition of prolyl hydroxylase, which in turn affects erythropoietin regulation, making it a promising agent for conditions characterized by low red blood cell counts.
Used in Chronic Kidney Disease Treatment:
In the medical field, 1,3,5-Trimethyl-4-nitro-1H-pyrazole is used as a potential treatment for anemia associated with chronic kidney disease. 1,3,5-TRIMETHYL-4-NITRO-1H-PYRAZOLE has demonstrated promising results in early clinical trials, suggesting its efficacy in managing anemia by modulating the body's erythropoietin response.
Used in Hypoxia and Tissue Ischemia Treatment:
1,3,5-Trimethyl-4-nitro-1H-pyrazole also has potential applications in the treatment of diseases related to hypoxia (low oxygen levels in tissues) and tissue ischemia (reduced blood supply to tissues). Its ability to influence erythropoietin levels could provide therapeutic benefits in these conditions, making it an important compound for further research and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 1125-30-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1125-30:
(6*1)+(5*1)+(4*2)+(3*5)+(2*3)+(1*0)=40
40 % 10 = 0
So 1125-30-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3O2/c1-4-6(9(10)11)5(2)8(3)7-4/h1-3H3

1125-30-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3,5-Trimethyl-4-nitro-1H-pyrazole

1.2 Other means of identification

Product number -
Other names 1,3,5-trimethyl-4-nitropyrazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1125-30-0 SDS

1125-30-0Relevant academic research and scientific papers

Reactions of pyrazoles and pyrazolium salts with complex metal hydrides and organometallic reagents. Synthesis of pyrazolines and pyrazolidines

Cuadrado, Purificacion,Gonzalez-Nogal, Ana M.,Martinez, Senen

, p. 8585 - 8598 (2007/10/03)

2-Pyrazolin-4-oximes have been synthesized by reaction of 4-nitroso- and 4-nitropyrazoles with complex metal hydrides and organometallic reagents. Furthermore, 4-nitropyrazolium tetrafluoroborates are reactive substrates towards organolithium and Grignard

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