3920-38-5

Usage

Uses

Used in Pharmaceutical Industry:
1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE is used as a building block for the synthesis of various pharmaceuticals, leveraging its chemical properties to contribute to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE serves as a key component in the creation of different agrochemicals, potentially enhancing crop protection and management strategies.
Given the hazardous nature of DMNP, it is crucial that its applications are carefully managed and controlled to mitigate risks associated with its toxicity and flammability.

InChI:InChI=1S/C5H7N3O2/c1-4-5(8(9)10)3-7(2)6-4/h3H,1-2H3

Upstream product

• 694-48-4 1,3-dimethyl-1H-pyrazole 
• 5334-39-4 3-methyl-4-nitro-1H-pyrazole 
• 74-88-4 methyl iodide 
• 6647-97-8 4-iodine-1,3-dimethyl-1H-pyrazole 
• 960502-51-6 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)acetohydrazide 
• 66971-55-9 5-hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole 

Downstream Products

• 119071-38-4 1,3-Dimethyl-4-nitro-5-(tosylmethyl)pyrazol 
• 64517-88-0 1,3-dimethyl-1H-pyrazol-4-amine 
• 1125-30-0 1,3,5-trimethyl-4-nitro-1H-pyrazole 
• 193147-02-3 4-hydroxyimino-1,3,5,5-tetramethyl-2-pyrazoline 
• 76689-64-0 5-amino-1,3-dimethyl-4-nitro-1H-pyrazole 

Relevant academic research and scientific papers

Alkynyl pyrimidine or alkynyl pyridine compound as well as composition and application thereof

The invention relates to alkynyl pyrimidine or alkynyl pyridine compounds represented by a formula (I) or pharmaceutically acceptable salts, isomers, solvates, crystals or prodrugs thereof. The invention also discloses a pharmaceutical composition contain

4-amino-1,3-dimethyl pyrazol and compound method for pharmaceutical acceptable salt thereof

The invention discloses 4-amino-1,3-dimethyl pyrazol and a compound method for pharmaceutical acceptable salt thereof. The method comprises the following steps: taking methylhydrazine and 4,4-dimethoxy-2-butanone as initial raw materials; firstly, compounding 1,3-dimethyl pyrazol, and then adding concentrated nitric acid for nitrating, thereby acquiring 4-nitro-1,3-dimethyl pyrazol; and directly reducing into the pharmaceutical acceptable salt or reducing nitro into amino and then converting into 4-amino-1,3-dimethyl pyrazol. The raw materials used in the compound method disclosed by the invention are low in cost and are easily acquired. According to the invention, the compounding route is short, the yield is high, and the acquired products are high in chemical purity; all the reactions require no special production equipment; and column chromatography and crystallizing purification are not required for the acquired intermediates and end products.

SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.

Faujasite catalyzed nitrodeiodination of iodopyrazoles

Nitrodeiodination of iodopyrazoles using nitric acid/Faujasite has been investigated. The present procedure is simple, rapid and convenient and requires no sulfuric acid or oleum and may be applied for the synthesis of several nitropyrazoles in good yield

A simple and environmentally benign nitration of pyrazoles by impregnated bismuth nitrate

We report herein a facile, rapid, and environmentally friendly synthesis of nitropyrazoles in good yields using silica-bismuth nitrate and silica-sulfuric acid-bismuth nitrate at room temperature for the first time. The relatively non-toxic nature, ease o

Silica-sulfuric acid catalyzed nitrodeiodination of iodopyrazoles

We report here the synthesis of nitropyrazoles in good to excellent yields from iodopyrazoles over silica-sulfuric acid catalyst for the first time. The present procedure require less acid, offers a simplified workup procedure, and may be applied for the

Facile and environmentally friendly synthesis of nitropyrazoles using montmorillonite K-10 impregnated with bismuth nitrate

Nitropyrazoles in higher yields were synthesized using montmorillonite K-10 impregnated with bismuth nitrate and the present procedure may be applied for the nitration of a wide variety of azoles in the drug and pharmaceutical industries.

CAN-mediated oxidation of electron-deficient aryl and heteroaryl hydrazines and hydrazides

Aryl and heteroaryl hydrazines and hydrazides were successfully oxidised using CAN, deriving dehydrazinated products. The reaction pathway strongly depends on the nature of the substrate, resulting in the formation of hydrocarbons or alkoxy derivatives. When deuterated solvents such as methanol-d4 or acetonitrile-d3 were used, a regiospecific incorporation of deuterium was achieved. Georg Thieme Verlag Stuttgart.

Nitrodeiodination of 4-iodo-1-methylpyrazoles

4-Iodo-1-methylpyrazoles react with a nitrating mixture at 55°C to give the corresponding 4-nitro-1-methylpyrazoles. The qualitative dependence of the nitrodeiodination rate on the structure of the heterocycles and the reaction conditions was considered.

Azoles, 26. - Vicarious Nucleophilic Substitution of Hydrogen in Nitropyrazole Derivatives

4-Nitropyrazoles 1a-1c and 1g-1j react with the carbanion derived from chloromethyl p-tolyl sulfone (2) to give products of the vicarious nucleophilic substitution (VNS) of hydrogen at position 5.The presence of a second nitro group at position 3 (1c) or