1125-96-8

Basic information

• Product Name: 2-(3-Pyridinyl)-2-pyrroline
• Synonyms: 2-(3-Pyridinyl)-2-pyrroline;3-(2-Pyrrolin-2-yl)pyridine;Myosmine, May Contain up to 2% Water
• CAS NO: 1125-96-8
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.19
• Mol File: 1125-96-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 318.7°C at 760 mmHg
• Flash Point: 146.5°C
• Appearance: /
• Density: 1.095g/cm³
• Vapor Pressure: 0.000356mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2-(3-Pyridinyl)-2-pyrroline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Pyridinyl)-2-pyrroline(1125-96-8)
• EPA Substance Registry System: 2-(3-Pyridinyl)-2-pyrroline(1125-96-8)

Safety Data

• Hazardous Substances Data: 1125-96-8(Hazardous Substances Data)

Usage

Chemical class

2-Pyrrolines.

Molecular weight

131.17 g/mol.

Structure

Heterocyclic compound with a pyrroline ring and a pyridine ring.

Aromaticity

Highly aromatic.

Usage

Commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals.

Potential application

Development of new materials.

Importance

A valuable intermediate in organic synthesis.

Versatility

Despite its relatively simple structure, PPT has versatile properties that make it an important compound in the field of organic chemistry.

InChI:InChI=1/C9H10N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3-5,7,11H,2,6H2

Upstream product

• 1226127-81-6 4-amino-1-(3-pyridyl)-1-butanol 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 1308392-26-8 1-(butenyl)-3-(pyridine-3-carbonyl)pyrrolidin-2-one 

Downstream Products

• 22083-74-5 3-(1-methyl-pyrrolidin-2-yl)-pyridine 
• 5746-86-1 rac-nornicotine 

Relevant articles and documents

Synthesis method of (R, S-) nicotine

The invention belongs to the technical field of medical intermediates, and particularly relates to a synthesis method of (R, S-) nicotine. The method comprises the following steps: (1) taking methyl nicotinate and N-butenyl pyrrolidone as raw materials, and preparing N-butenyl-3-benzoyl-1-pyrrolidone through a condensation reaction; (2) after the reaction is finished, carrying out hydrolysis reaction, cooling, adjusting the pH value to be alkaline, extracting, separating out an organic phase, concentrating and distilling to obtain an enamine intermediate; and (3) carrying out a reduction reaction on the enamine intermediate under illumination with the wavelength of 200-400nm by using a metal oxide or a complex as a reduction catalyst to obtain the target product (R, S-) nicotine. According to the method, use of the metal catalyst is innovatively proposed, reaction is initiated by illumination with specific wavelength to prepare the (R, S-) nicotine, and the method is simple and convenient to operate, high in yield, low in cost and suitable for industrial large-scale production.

PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE

A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.