112500-68-2Relevant articles and documents
Convenient synthesis of pyrido[4,3-D]pyrimidine-2,4(1H,3H)-diones
Hirota, Kosaku,Nakazawa, Yukio,Kitade, Yukio,Sajiki, Hironao
, p. 871 - 882 (2007/10/03)
A convenient synthesis of pyrido[4,3-d]pyrimidine-2,4(1H,3H)-diones is described. Treatment of 5-formyl-1,3-dimethyl-6-(2-dimethylamino)vinyluracil (1) with ammonia and hydrazines affords the corresponding pyrido[4,3-d]pyrimidine-2,4(1H,3H)-diones (2 and 3), respectively. Similar reaction of 5-cyano- and 5-ethoxycarbonyluracils (10 and 15) with ammonia led to formation of 5-amino- and 5-hydroxylpyrido[4,3-d]pyrimidine-2,4(1H,3H)-diones (11 and 16), respectively.