112545-97-8

Basic information

• Product Name: 2,2-difluoro-1,2-bis(4-methoxyphenyl)ethan-1-one
• Synonyms: 2,2-difluoro-1,2-bis(4-methoxyphenyl)ethan-1-one
• CAS NO: 112545-97-8
• Molecular Weight: 292.282
• Mol File: 112545-97-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-1,2-bis(4-methoxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-1,2-bis(4-methoxyphenyl)ethan-1-one(112545-97-8)
• EPA Substance Registry System: 2,2-difluoro-1,2-bis(4-methoxyphenyl)ethan-1-one(112545-97-8)

Safety Data

• Hazardous Substances Data: 112545-97-8(Hazardous Substances Data)

Upstream product

• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 623-12-1 4-chloromethoxybenzene 
• 114829-07-1 ω,ω-Difluoro-4-methoxyacetophenone 
• 104-92-7 1-bromo-4-methoxy-benzene 

Relevant articles and documents

Pd-catalyzed α-arylation of α,α-difluoroketones with aryl bromides and chlorides. A route to difluoromethylarenes

We report the Pd-catalyzed α-arylation of α,α- difluoroketones with aryl and heteroaryl bromides and chlorides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)Cy2 as ligand. The combination of this Pd-catalyzed arylation and base-induced cleavage of the acyl-aryl C-C bond within the α-aryl-α,α- difluoroketone constitutes a one-pot, two-step procedure to synthesize difluoromethylarenes from aryl halides. A broad range of electronically varied aryl and heteroaryl bromides and chlorides underwent these two transformations, providing α-aryl-α,α-difluoroketones, difluoromethylarenes, and difluoromethylheteroarenes in high yields.

Palladium catalyzed direct α-arylation of α,α- difluoroketones with aryl bromides

The palladium-catalyzed direct α-arylations of α,α- difluoroketones with diverse aryl bromides have been developed by using rac-BINAP as ligand and Cs2CO3 as a mild base in xylene. This method provides an efficient and straightforward access to a variety of α-aryl-α,α-difluoroketones with broad substrate scope.

NOUVELLE METHODE DE PREPARATION DE CETONES, ESTER ET NITRILE BENZYLIQUES α-FLUORES OU α,α-DIFLUORES

By anodic oxidation in CH3CN/Et3N, 3HF benzylic ketones, ester and nitrile yield specifically corresponding monofluoro or difluoro compounds.The reaction proceeds through an α-carbonyl or an α-cyano carbocation.