1125474-24-9

Basic information

• Product Name: 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride
• Synonyms: 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride
• CAS NO: 1125474-24-9
• Molecular Weight: 368.904
• Mol File: 1125474-24-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride(1125474-24-9)
• EPA Substance Registry System: 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride(1125474-24-9)

Safety Data

• Hazardous Substances Data: 1125474-24-9(Hazardous Substances Data)

Upstream product

• 1125474-22-7 (4-isopropylpiperazin-1-yl)(4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)methanone 
• 4318-42-7 1-(1-methylethyl)piperazine 
• 851048-51-6 4-(3,4,5,6-tetrahydro-2H-pyran-4-yloxy)benzoic acid 
• 892501-93-8 4-(tetrahydro-2H-pyran-4-yloxy)benzoyl chloride 

Relevant articles and documents

PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR

The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine (Formula) or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.