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Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole, which is structurally related to ketoconazole. It is formed by the metabolism of itraconazole through the cytochrome P450 isoform 3A4 (CYP3A4). Hydroxy itraconazole exhibits in vitro antifungal activity against various fungal strains, such as C. albicans, A. fumigatus, and C. neoformans. It is also a COVID-19-related research product and is characterized as an off-white crystalline solid.

112559-91-8

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112559-91-8 Usage

Uses

Used in Antifungal Applications:
Hydroxy itraconazole is used as an antifungal agent for treating and preventing fungal infections. Its in vitro antifungal activity makes it effective against various fungal strains, including C. albicans, A. fumigatus, and C. neoformans. The plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound, itraconazole, and is used as an indicator of prophylaxis for fungal infections.
Used in COVID-19 Research:
Hydroxy itraconazole is also used as a COVID-19-related research product, potentially contributing to the development of treatments or therapies for the virus. Its antifungal properties and ability to modulate immune responses may offer insights into its potential application in combating COVID-19.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, hydroxy itraconazole is used as an active ingredient in the development of antifungal medications. Its potent antifungal activity and ability to serve as an indicator of prophylaxis make it a valuable compound for creating effective treatments for fungal infections.
Used in Research and Development:
Hydroxy itraconazole is utilized in research and development for its potential applications in various fields, including antifungal therapy, COVID-19 research, and other medical applications. Its unique properties and metabolite status make it an interesting subject for further investigation and potential development of new drugs or therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 112559-91-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,5,5 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 112559-91:
(8*1)+(7*1)+(6*2)+(5*5)+(4*5)+(3*9)+(2*9)+(1*1)=118
118 % 10 = 8
So 112559-91-8 is a valid CAS Registry Number.
InChI:InChI=1/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3/t24?,25?,31-,35-/m0/s1

112559-91-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Hydroxy Itraconazole

1.2 Other means of identification

Product number -
Other names HYDROXY ITRACONAZOLE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112559-91-8 SDS

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112559-91-8Related news

A simple, sensitive HPLC-PDA method for the quantification of itraconazole and HYDROXY ITRACONAZOLE (cas 112559-91-8) in human serum: a reference laboratory experience07/25/2019

A chromatographic method (high-performance liquid chromatography/photodiode array detection) for the simultaneous determination of itraconazole and its mayor metabolite, hydroxy itraconazole, was developed. The validation data demonstrated acceptable values for linearity (dynamic range between 0...detailed

Ultra-performance liquid chromatography electrospray ionization–tandem mass spectrometry method for the simultaneous determination of itraconazole and HYDROXY ITRACONAZOLE (cas 112559-91-8) in human plasma07/24/2019

A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid–liquid extraction step. The precursor to pro...detailed

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