1125595-63-2Relevant academic research and scientific papers
Synthesis of Unsymmetrical α,α-Diarylacetates
Jadhav, Santosh D.,Singh, Anand
, p. 522 - 531 (2016)
Ethyl bromofluoroacetate has been developed as a precursor for the convenient synthesis of unsymmetrical α,α-diarylacetates featuring indoles, anilines, and other electron-rich aromatics. In conjunction with a mild Lewis acid catalyzed C-N → C-C exchange, intermediate arylglycines can be synthesized and transformed into α,α-diarylacetates in a one-pot protocol, resulting in a net diarylation reaction exhibiting a wide scope. In the context of diarylacetates, the synthetic equivalence of the fluorinated reagent with α-nitro-α-diazo carbonyls was established.
Arylation of diazoesters by a transient N-H insertion organocascade
Auvil, Tyler J.,So, Sonia S.,Mattson, Anita E.
, p. 11317 - 11320 (2013)
It takes two: A unique organocatalyzed cascade for the unsymmetric double arylation of α-nitrodiazoesters is described. This organocascade features the strategic use of carbene-activating anilines in conjunction with a urea catalyst, thus allowing for the
News from the 80-year-old passerini variant of the Friedel-Crafts alkylation of indole
Desimoni, Giovanni,Faita, Giuseppe,Mella, Mariella,Toscanini, Marco,Boiocchi, Massimo
experimental part, p. 6232 - 6238 (2009/06/18)
The multi-component Friedel-Crafts alkylation reaction between indole (1), ethyl glyoxylate (2) and anilines (3a-f) gives, in analogy to the protocol of the old Passerini reaction, the expected ethyl 2-(arylamino)-2-(1H-indol-3-yl) acetates 4a-f. When the
