867003-44-9

Upstream product

• 120-72-9 indole 
• 924-44-7 glyoxylic acid ethyl ester 
• 62-53-3 aniline 
• 2216-92-4 N-phenylglycine ethyl ester 
• 121642-09-9 ethyl 2-(phenylimino)acetate 

Downstream Products

• 1125595-63-2 ethyl 2-(4-aminophenyl)-2-(1H-indol-3-yl)acetate 
• 1125595-66-5 ethyl 2-({4-[(ethoxycarbonyl)(1H-indol-3-yl)methyl]phenyl}amino)-2-(1H-indol-3-yl)acetate 

Relevant academic research and scientific papers

Synthesis method of alpha-indolylglycine derivative

The invention discloses a synthesis method of an alpha-indolylglycine derivative. The synthesis method uses a glycine derivative and a substituted indole as raw materials, acetonitrile as a solvent, and organic dye Bengal rose red as a photocatalyst to sy

Co-catalyzed C(sp3)-H oxidative coupling of glycine and peptide derivatives

Cobalt-catalyzed selective a-alkylation and a-heteroarylation processes of a-amino esters and peptide derivatives are described. These cross-dehydrogenative reactions occur under mild conditions and allow for the rapid assembly of structurally diverse a-amino carbonyl compounds. Unlike enolate chemistry, these methods are distinguished by their site-specificity, occur without racemization of the existing chiral centers, and exhibit total selectivity for aryl glycine motifs over other amino acid units, hence providing ample opportunities for peptide modifications.

Iron-catalyzed direct α-arylation of α-amino carbonyl compounds with indoles

A mild and general α-arylation of α-amino carbonyls with indoles catalyzed by Fe(ClO4)3 has been developed. C-H activation is smoothly fulfilled by using TBHP as the oxidant with good yields. Two hydrogen dissociations make this transformation more environmentally benign because of high atom efficiency.

Copper(I) chloride-catalyzed aerobic oxidative arylation of glycine ester and amide derivatives

A simple and efficient copper(I) chloridecatalyzed aerobic oxidative coupling of glycine derivatives (glycine esters, glycine amides and short peptides) with indoles has been developed. The reaction is performed in the absence of any other additives under mild conditions and only requires simple copper salts as a catalyst and oxygen as a cooxidant.

Merging visible-light photoredox and Lewis acid catalysis for the functionalization and arylation of glycine derivatives and peptides

A relay catalysis protocol for the functionalization of α-amino acids and dipeptides using a combination of visible-light photoredox and Lewis acid catalysis has been developed. The Royal Society of Chemistry.

News from the 80-year-old passerini variant of the Friedel-Crafts alkylation of indole

The multi-component Friedel-Crafts alkylation reaction between indole (1), ethyl glyoxylate (2) and anilines (3a-f) gives, in analogy to the protocol of the old Passerini reaction, the expected ethyl 2-(arylamino)-2-(1H-indol-3-yl) acetates 4a-f. When the

Three-component Friedel-Crafts reaction of indoles, glyoxylate, and amine under solvent-free and catalyst-free conditions - Synthesis of (3-indolyl)glycine derivatives

Solvent-free and catalyst-free three-component reactions of indoles, amines, and ethyl glyoxylate gave alkylation products in good to high yields (61-93%), providing a convenient synthesis of (3-indolyl)glycine derivatives. Georg Thieme Verlag Stuttgart.

Synthesis of α-(3-indolyl)glycine derivatives via spontaneous Friedel-Crafts reaction between indoles and glyoxylate imines

Mannich-type Friedel-Crafts reaction between indoles and ethyl glyoxylate imines proceeded spontaneously in the absence of an acid catalyst. Ethyl α-(3-indolyl)glycinates were obtained in moderate to high yields. Reaction with (R)-α-methylbenzylamine deri