112561-22-5Relevant academic research and scientific papers
IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines
Gao, Peng,Chen, Huai-Juan,Bai, Zi-Jing,Zhao, Mi-Na,Yang, Desuo,Wang, Juan,Wang, Ning,Du, Lele,Guan, Zheng-Hui
, p. 7939 - 7951 (2020/07/16)
An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alcohol, followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.
PYRIDYLPYRROLE COMPOUNDS USEFUL AS INTERLEUKIN-AND TNF ANTAGONISTS
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, (2008/06/13)
The present invention provides a compound of the formula: and its pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5 and m are as defined in claim 1. The present invention also provides processes for the preparation thereof, the use thereof in treating cytokines mediated diseases and/or cell adhesion molecules (CAMs) mediated diseases and pharmaceutical compositions for use in such therapy.
Palladium catalysed synthesis of pyrroles from enamines
Grigg, Ronald,Savic, Vladimir
, p. 873 - 874 (2007/10/03)
Substituted pyrroles are formed in moderate to good yields by the Pd- catalysed cyclisation of enamines containing β-vinyl bromide functionalities.
Aminosilanes in Organic Synthesis. Addition of Organocopper Reagents on γ-Bis(trimethylsilyl)amino-α-Acetylenic Amides, Esters and Ketones. Stereochemistry und Some Synthetic Uses
Corriu, Robert J. P.,Bolin, Geng,Iqbal, Javed,Moreau, Joel J. E.,Vernhet, Claude
, p. 4603 - 4618 (2007/10/02)
The stereochemical outcome of the carbocupration of γ-bis(trimethylsilyl)amino-α-acetylenic amide, esters and ketone was studied.A judicious choice of substrate, reagent and(or) reaction conditions allows to perform highly stereoselective cis or trans addition.The intermediate vinylic copper adducts, with (E) or (Z) configuration, react with electrophilic reagents to provide short routes to substituted pyrrolinones and pyrroles.Keywords: Silylamines, propargylamines, organocopper regaents, stereochemistry, nitrogen heterocycles.
SILYLAMINES IN ORGANIC SYNTHESIS : A NEW ACCESS TO FUNCTIONAL PYRROLES VIA ORGANOCUPRATES ADDITION ON METHYL-BIS(TRIMETHYLSILYL)AMINOMETHYLPROPIOLATE
Corriu, Robert J.P.,Moreau, Joel J.E.,Vernhet, Claude
, p. 2963 - 2966 (2007/10/02)
Organocuprate addition reactions on methyl-bis(trimethylsilyl)aminomethylpropiolate lead to the formation of a Z-vinyl cuprate with a high stereoselectivity.Upon reaction of acid chloride, pyrroles are formed by a spontaneous intramolecular cyclisation of the intermediate Z-silylamino enone.Various functional substituted pyrroles can be obtained in one step by this route.
