112561-79-2

Upstream product

• 134017-42-8 methyl 2-(2-methoxyacetamido)benzoate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 112561-82-7 2-(N-(2-methoxyethyl)-N-methylamino)benzyl alcohol 
• 134017-56-4 2-[2-(2-methoxyethylamino)benzylthio]imidazole 
• 112561-83-8 2-(N-(2-methoxyethyl)-N-methylamino)benzaldehyde 
• 112562-88-6 2-{2-[(2-Methoxy-ethyl)-methyl-amino]-phenyl}-thiazolidine-3-carbothioic acid methylamide; hydrochloride 
• 134017-66-6 2-[2-(2-methoxyethylamino)benzylsulfinyl] imidazole 

Relevant academic research and scientific papers

Sulfinyl imidazole derivatives and antiulcer agents containing the same

Disclosed are novel imidazole derivatives having the formula: STR1 wherein R1 is hydrogen or an alkyl group having 1-6 carbon atoms, R2 is an alkyl group having 2-6 carbon atoms substituted with an alkoxy group having 1-4 carbon atom

Synthesis and structure-activity relationships of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines as a new class of gastric H+/K+-ATPase inhibitors

A series of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines was synthesized and evaluated for its biological activity against H+/K+-ATPase prepared from rabbit stomach and gastric acid secretions in Heidenhain pouch dogs. Monoalkyl substituents on the nitrogen atom of the aniline moiety markedly inhibited the enzyme activity to the same degree as omeprazole, a representative H+/K+-ATPase inhibitor. Most of these compounds, administered at 3 mg/kg i.v. inhibited histamine-stimulated gastric acid secretion. The inhibitory activity of these derivatives on the enzymes at pH 6.0 was more potent than that at pH 7.4, and was distinctly correlated to stability in aqueous solution at pH 5.0.