112565-01-2

Upstream product

• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 827-41-8 3-phenylpyrazol-5-amine 
• 5667-47-0 phenacyldimethylsulfonium bromide 
• 333-20-0 potassium thioacyanate 
• 98664-16-5 α-bromo-α'(3-phenyl)pyrazolylglyoxalhydrazone 

Downstream Products

• 112565-03-4 2-nitrosoimino-2,3-dihydro-3-(3-phenyl-5-pyrazolyl)-5-benzoyl-1,3,4-thiadiazole 
• 112565-07-8 2-benzoylimino-2,3-dihydro-3-(1-benzoyl-3-phenyl-5-pyrazolyl)-5-benzoyl-1,3,4-thiadiazole 
• 112565-05-6 2-acetylimino-2,3-dihydro-3-(1-acetyl-3-phenyl-5-pyrazolyl)-5-benzoyl-1,3,4-thiadiazole 

Relevant academic research and scientific papers

The Structure of the Diazonium Coupling Products of Phenacyl Thiocyanate and Phenacyl Selenocyanate with Diazotized 3-Phenyl-5-Aminopyrazole

The reaction of diazotized 3-phenyl-5-aminopyrazole with phenacyl thiocyanate 1a and phenacyl selenocyanate 1b afforded directly 2-imino-3-(3-phenyl-5-pyrazolyl)-5-benzoyl-2,3-dihydro-1,3,4-thiadiazole monohydrate 9a and 2-imino-3-(3-phenyl-5-pyrazolyl)-5

Synthesis of Some New 2-Imino-2,3-dihydro-1,3,4-thiadiazole and Selenadiazole Derivatives

Diazotized 3(5)-amino-5(3)-phenylpyrazole (2) reacts with phenacylthiocyanate (1) and phenacylselenocyanate (10) to give the corresponding 1,3,4-thiadiazoline derivative (5) and 1,3,4-selenadiazoline derivative (12), respectively.A mechanism is proposed and it is substantiated by an alternate synthesis of 5 and 12 from the corresponding hydrazidoyl bromide (6) with potassium thiocyanate and potassium selenocyanate, respectively.The thiadiazoline (5) and selenadiazoline (12) give the respective N-acyl derivatives (7a) and (12) with acetic anhydride.Nitrosation of 5 and 12 gives the corresponding N-nitroso-derivatives (8a) and (14), respectively.Cyclization of 6 gives the corresponding 9 with triethylamine in benzene. - 2-Imino-2,3-dihydro-1,3,4-thiadiazole, Selenadiazole Derivatives