112571-68-3

Usage

Uses

Used in Pharmaceutical Industry:
DL-Myo-Inositol 1,4,5-Tris(dihydrogen Phosphate) Hexaammonium Salt is used as a therapeutic agent for the treatment and management of various diseases associated with the dysregulation of the calcium signaling system. Its application in this industry is due to its ability to control the release of Ca2+ ions, which is essential for maintaining the proper functioning of cellular processes.
Used in Research and Development:
DL-Myo-Inositol 1,4,5-Tris(dihydrogen Phosphate) Hexaammonium Salt is used as a research tool for studying the role of calcium signaling in cellular processes and the development of new therapeutic strategies for diseases related to calcium signaling dysregulation. Its application in this field is due to its direct involvement in the regulation of Ca2+ signaling system.
Used in Diagnostics:
DL-Myo-Inositol 1,4,5-Tris(dihydrogen Phosphate) Hexaammonium Salt is used as a diagnostic marker for identifying and monitoring the progression of diseases associated with the dysregulation of the calcium signaling system. Its application in this industry is due to its direct involvement in the regulation of Ca2+ ions, which can be indicative of the presence or severity of certain diseases.

Upstream product

• 112489-44-8 C₃₀H₃₁Br₂O₁₆P₃ 
• 112489-46-0 C₁₁H₁₅O₁₅P₃^(6-)*6H₄N⁽¹⁺⁾ 
• 116096-44-7 C₃₄H₄₄O₈ 
• 13035-68-2 C₃₂H₄₀O₆ 
• 116096-45-8 C₂₈H₃₆O₈ 
• 13035-66-0 C₂₆H₃₂O₆ 
• 115509-76-7 (-)-1D-2,5,6-tri-O-benzyl-myo-inositol 
• 6763-49-1 (±)-1,2:3,4-di-O-cyclohexylidene-myo-inositol 
• 6763-49-1 (+/-)-1,2:5,6-dicyclohexylidene-myo-inositol 
• 87-89-8 D-myo-inositol 
• 115510-58-2 (+)-1D-2,5,6-tri-O-benzyl-1,3,4-tris(dibenzylphospho)-myo-inositol 
• 104873-74-7 1D-1,4,5-tri-O-allyl-3,6-di-O-benzyl-myo-inositol 
• 104826-12-2 (+/-)-4,5-di-O-allyl-3,6-di-O-benzyl-1,2-O-cyclohexylidene-myo-inositol 
• 98925-52-1 (+/-)-5,6-di-O-allyl-1,4-di-O-benzyl-myo-inositol 

Relevant academic research and scientific papers

A chemoenzymatic synthesis of D-myo-inositol 1,4,5-trisphosphate

Enzyme-catalyzed esterification of racemic 2,3-O-cyclohexylidene-myo-inositol (DL-1) proceeded exclusively in 1,4-dioxane to give optically pure L-1-O-acetyl-2,3-O-cyclohexylidene-myo-inositol (L-2) and D-2,3-O-cyclohexylidene-myo-inositol (D-1).A new practical route has been developed for the synthesis of D-myo-inositol 1,4,5-trisphosphate starting from D-1 via selective acylation of the 6-hydroxyl group.

Synthesis and Some Properties of D-myo-Inositol 1,4,5-Tris(dihydrogen phosphate)

Optically active myo-inositol 1,4,5-tris(dihydrogen phosphate) 1, which has now been recognized as a second messenger in a new intracellular signal transduction system, has been prepared starting from myo-inositol.The key step, phosphorylation of an adequately protected polyhydroxy derivative, was accomplished by three methods, among which a phosphoramidite method using a new phosphitylating agent, o-xylylene N,N-diethylphosphoramidite, gave the triphosphoric ester in quantitative yield.Optical resolution was effectively realized by derivatization into diastereoisomeric l-menthoxyacetic esters.NMR spectra and optical rotation are shown to depend on the pH of an aqueous solution of compound 1.

Synthesis of Optically Active myo-Inositol 1,3,4-Triphosphate

Synthesis of optically active myo-inositol 1,3,4-triphosphate has been accomplished.Efficiency of a chiral HPLC column for optical resolution of myo-inositols is shown.

SYNTHESIS OF D-myo-INOSYTOL 1,4,5-TRIPHOSPHATE

The conversion of myo-inositol into the ammonium salts both of racemic and enantiomerically pure D-myo-inositol 1,4,5-triphosphate (6) is described.The n.m.r. spectroscopic properties and biological activity of synthetic and naturally-isolated (6) are virtually identical.