112592-90-2Relevant academic research and scientific papers
Enantiospecific C-H Activation Using Ruthenium Nanocatalysts
Taglang, Céline,Martínez-Prieto, Luis Miguel,Del Rosal, Iker,Maron, Laurent,Poteau, Romuald,Philippot, Karine,Chaudret, Bruno,Perato, Serge,Sam Lone, Ana?s,Puente, Céline,Dugave, Christophe,Rousseau, Bernard,Pieters, Grégory
, p. 10474 - 10477 (2015)
The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.
Thioacylating Agents. Use of Thiobenzimidazolone Derivatives for the Preparation of Thiotuftsin Analogs.
Zacharie, Boulos,Sauve, Gilles,Penney, Christopher
, p. 10489 - 10500 (2007/10/02)
The properties and characteristic reactions of thioacylating reagents 1 are described.These reagents are able to introduce thioamide linkages into a growing peptide at a specific site in the sequence.The generality and efficiency of this methodology is demonstrated by the synthesis of the three monothioanalogues of tuftsin.
Method for protecting guanidino group and restoring the same
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, (2008/06/13)
A guanidino group in an amino acid or a peptide can be protected with a specific protective group, i.e. lower alkoxybenzenesulfonyl group or tri-lower alkylbenzenesulfonyl group, and the protective group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the method is useful in the related chemical industries, especially in the peptide synthesis.
