1126-12-1Relevant academic research and scientific papers
CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD
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Page 222, (2010/02/06)
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0,1 or 2; R is H, alkyl, aryl or halogen; A is (1) a bond; (2) -O-; or (3) (i); B is: (ii) or (iii) or (iv) or (v) (wherein (a = 2, 3 or 4)) or (vi) or (vii) or (viii); and wherein L, L, R, R, R, R, R, R, R, R, R, X, (ix), (x) and (xi) are as defined herein.
Convenient Synthesis of 4-Methoxy-3-nitro-1,2-benzenediamine and its Conversion into 6-Methoxy-5-nitroquinoxalines
Grivas, Spiros,Tian, Wei
, p. 1109 - 1113 (2007/10/02)
4-Methoxy-3-nitro-1,2-benzenediamine (6) has been prepared through nitration of 5-methoxy-2,1,3-benzoselenadiazole, followed by reductive removal of the selenium.Cyclocondensation of 6 with α-dicarbonyl compounds afforded the title quinoxalines, some of them novel and not easily obtainable by direct nitration.Methyl- or phenylglyoxal gave mixtures of quinoxalines in proportions strongly influenced by the acidity of the reaction medium.
