1126223-57-1

Basic information

• Product Name: 4-chloro-3-ethyl-5-hydroxymethyl-1-methyl -1H-pyrazole
• Synonyms: 4-chloro-3-ethyl-5-hydroxymethyl-1-methyl -1H-pyrazole
• CAS NO: 1126223-57-1
• Molecular Formula: C7H11ClN2O
• Molecular Weight: 174.62804
• Product Categories: Heterocycle
• Mol File: 1126223-57-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-3-ethyl-5-hydroxymethyl-1-methyl -1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3-ethyl-5-hydroxymethyl-1-methyl -1H-pyrazole(1126223-57-1)
• EPA Substance Registry System: 4-chloro-3-ethyl-5-hydroxymethyl-1-methyl -1H-pyrazole(1126223-57-1)

Safety Data

• Hazardous Substances Data: 1126223-57-1(Hazardous Substances Data)

Upstream product

• 128537-26-8 3-ethyl-1-methylpyrazole-5-carboxylic acid ethyl ester 
• 26308-40-7 ethyl 3-ethyl-1H-pyrazole-5-carboxylate 
• 128537-31-5 1-methyl-3-ethyl-4-chloro-5-pyrazolecarboxylic acid methyl ester 
• 129560-00-5 1-methyl-3-ethyl-4-chloro-1H-pyrazol-5-ylformylic acid chloride 

Downstream Products

• 1182281-78-2 4-chloro-5-(chloromethyl)-3-ethyl-1-methyl-1H-pyrazole 
• 1182280-69-8 N-(4-chloro-5-ethyl-2-methyl-2H-pyrazol-3-ylmethyl)-4-(5-trifluoromethyl-pyridin-2-yloxy)-benzenesulfonamide 

Relevant articles and documents

Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage

A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell lines in vitro, superior to 5-FU. The most potent compound 10M selectively inhibited human hepatocellular carcinoma cells but not non-tumor liver cell proliferation in vitro, and significantly triggered SMMC-7721 cell apoptosis by cleavage of both PARP and caspase-3 in a concentration-dependent manner. Further study revealed that the potent activity in the cell growth inhibition and apoptosis induction effects of 10M were related to DNA damage and activation of the p53 signaling pathway. Moreover, 10M showed low acute toxicity to mice and significant growth inhibition of the hepatoma tumor in vivo.

N - methyl - 3 - ethyl - 4 - chlorine pyrazole derivative compounds

The invention discloses an N-methyl-3-ethyl-4-hlorine pyrrole derivative compound with insecticidal/acaricidal activities and an isomer thereof shown in formula (I) and formula (II) and a preparation method thereof. The N-methyl-3-ethyl-4-hlorine pyrrole derivative compound has the insecticidal/acaricidal activities and is used for controlling armyworms, aphids and mites on crops, and the formulations of the N-methyl-3-ethyl-4-hlorine pyrrole derivative compound comprise a concentrated emulsion, missible oil, a suspending agent and wettable powder.

SUBSTITUTED SULFONIC ACID AMIDE COMPOUNDS

The present invention relates to the use of substituted sulfonic acid amide compounds of formula I, wherein Ra, n, Het, A, Y and D are as defined in the claims and the N-oxides and the salts thereof for combating phytopathogenic harmful fungi,