26308-40-7

Basic information

• Product Name: 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester
• Synonyms: 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester;5-Ethyl-1H-pyrazole-3-carboxylic acid ethyl ester;1H-Pyrazole-3-carboxylic acid, 5-ethyl-, ethyl ester
• CAS NO: 26308-40-7
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.19
• Mol File: 26308-40-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 319.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.134±0.06 g/cm3(Predicted)
• PKA: 11.60±0.10(Predicted)
• CAS DataBase Reference: 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester(26308-40-7)
• EPA Substance Registry System: 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester(26308-40-7)

Safety Data

• Hazardous Substances Data: 26308-40-7(Hazardous Substances Data)

Usage

General Description

5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H12N2O2. It is an ethyl ester derivative of 5-ethyl-2H-pyrazole-3-carboxylic acid, which is an important building block for the synthesis of pharmaceuticals and agrochemicals. 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester is commonly used as an intermediate in the synthesis of various organic compounds, and it is also used in research and development in the pharmaceutical and agrochemical industries. It is a colorless to pale yellow liquid with a slightly fruity odor, and it is typically stored and handled under inert atmosphere to prevent oxidation and degradation. Overall, 5-Ethyl-2H-pyrazole-3-carboxylic acid ethyl ester is a versatile and valuable chemical compound with a wide range of potential applications in the field of organic synthesis and chemical research.

Upstream product

• 64-19-7 acetic acid 
• 95-92-1 oxalic acid diethyl ester 
• 78-93-3 butanone 
• 302-01-2 hydrazine 
• 623-73-4 diazoacetic acid ethyl ester 
• 123-72-8 butyraldehyde 
• 13246-52-1 ethyl-2,4-dioxohexanoate 

Downstream Products

• 4027-59-2 3-Ethyl-1H-pyrazole-5-carboxylic Acid 
• 4027-59-2 5-ethyl-1⁽²⁾H-pyrazole-3-carboxylic acid 
• 1182281-78-2 4-chloro-5-(chloromethyl)-3-ethyl-1-methyl-1H-pyrazole 
• 1126223-57-1 1-methyl-3-ethyl-4-chloropyrazol-5-yl-methanol 
• 880495-48-7 C₇H₈BrClN₂O 
• 128537-48-4 C₇H₉BrN₂O₂ 
• 128537-28-0 ethyl 1-methyl-3-ethyl-4-bromine-1Hpyrazole-5-carboxylate 
• 26308-42-9 3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid 
• 1359764-56-9 C₁₅H₁₆ClN₃O 
• 1359764-55-8 C₂₀H₂₇N₃O₂ 
• 1359764-53-6 C₁₉H₂₅N₃O 

Relevant articles and documents

A two-fluoro the benzyl is wicked zole miticides (by machine translation)

The invention provides a two-fluoro the benzyl is wicked zole compound, structure such as shown in formula I: In the formula: R1 Is selected from methyl or ethyl; R2 Is selected from methyl, ethyl or tertiary butyl; R3 Selected from H or Cl. The formula I compound to the insects, mites of killing effect, can be regarded as insecticide, acaricide for pests in agriculture, digestion control. (by machine translation)

Pyrazole amide compound, and preparation method and application thereof

The invention discloses a pyrazole amide compound represented by the formula (I), and a preparation method and an application thereof, wherein R, R1, R2 and W have the definitions indicated in the specification. The compound represented by the formula (I) has bactericidal, insecticidal or acaricidal biological activities, and specially has quite high activity on pathogenic bacteria such as sphaerotheca fuliginea, botrytis cinerea, melampsora lini and the like.

Highly regioselective organocatalyzed synthesis of pyrazoles from diazoacetates and carbonyl compounds

A general, organocatalytic inverse-electron-demand [3+2] cycloaddition reaction between a range of carbonyl compounds and diazoacetates has been developed. This reaction is catalyzed by secondary amines as a "green promoter" to generate substituted pyrazoles with high levels of regioselectivity. It is noteworthy that this [3+2] cycloaddition reaction proceeds efficiently at room temperature with a simple and inexpensive catalyst. Considering the large variety and ready availability of the starting materials (e.g. ketones, β-ketoesters, β-diketones, and aldehydes), as well as the operational simplicity of this process, a convenient, practical, and highly modular pyrazole synthesis has been developed. We believe that this work will arouse more research interest in the organocatalytic synthesis of other biologically active heterocycles. Such studies are currently underway in our laboratory. Dipoles apart: In situ formed enamines react with diazoacetates under mild conditions to afford the corresponding polysubstituted pyrazoles in good-to-excellent yields through an inverse-electron-demand 1,3-dipolar cycloaddition process (see scheme). Copyright