112635-44-6

Upstream product

• 3360-53-0 1-bromo-2-phenyl-1-propene 
• 849728-02-5 ((E)-2-Phenyl-propenyl)-phosphonic acid monoethyl ester 
• 98-83-9 isopropenylbenzene 
• 98064-18-7 (Z)-2-Phenyl-1,3-bis(trimethylsilyl)-2-phenylprop-1-ene 
• 140149-89-9 3-Bromo-3-(trimethylsilyl)-2-phenyl-1-propene 
• 16917-35-4 (E)-(1-bromoprop-1-en-2-yl)benzene 

Downstream Products

• 112635-47-9 1-((E)-3-Bromo-2-phenyl-allyloxy)-4-methyl-benzene 
• 112635-55-9 4-((E)-3-Bromo-2-phenyl-allyloxy)-biphenyl 
• 112635-53-7 1-((E)-3-Bromo-2-phenyl-allyloxy)-4-methoxy-benzene 
• 112635-51-5 1-((E)-3-Bromo-2-phenyl-allyloxy)-2,4-dichloro-benzene 
• 112635-45-7 C₁₅H₁₃BrO 
• 6054-00-8 3-phenyl-2H-benzopyran 
• 88040-01-1 6-chloro-3-phenyl-2H-benzopyran 
• 88039-97-8 6-Methoxy-3-phenyl-2H-chromene 
• 112635-57-1 6-Methyl-3-phenyl-2H-chromene 
• 112635-58-2 6,8-Dichloro-3-phenyl-2H-chromene 
• 112635-59-3 3,6-Diphenyl-2H-chromene 

Relevant academic research and scientific papers

Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process

The intramolecular fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [18F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of 18F-labeled heterocycles with high radiochemical purity.

Synthesis of 1-Aryltetralins and 1-Arylnaphthalenes via (4 + 2) Annulation of β-Ketosulfones with Styryl Bromides

A novel route has been developed for the synthesis of various substituted 1-aryltetralins 6 and 1-arylnaphthalenes 8 via (1) K2CO3-mediated α-styrylation of β-ketosulfones 3 with bromostyryl bromides 4 and (2) stereocontrolled NaBH4-promoted reduction of the resulting γ-alkenones 5, followed by BF3·OEt2-catalyzed intramolecular annulation of the corresponding γ-alkenols 7 under rt/5 h and reflux/10 h conditions, respectively. The key structures of 6 and 8 were confirmed by X-ray crystallographic analysis. A plausible mechanism has been proposed.

NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.

Halodephosphorylation of α,β-unsaturated phosphonic acid monoesters

Reaction of α,β-ethylenic and acetylenic phosphonic acid monoesters with (biscollidine)iodine(I) or (biscollidine)bromine(I) hexafluorophosphate led to α,β-unsaturated halides by, without precedent, dephosphorylation reactions.

Potential GABAB Receptor Antagonists. VI. The Synthesis of Saclofen and Other Sulfonic Acid Derivatives

Saclofen, 3-amino-2-(4-chlorophenyl)propanesulfonic acid (3), has been synthesized by two routes.Attempts to hyrogenolyse or dehydrate the 2-hydroxy derivative were unsuccessful, however.Radical sulfonation of 3-amino-1-bromo-2-(4-chlorophenyl)propene gav

A Novel two-step Synthesis of 3-Phenyl-2H-1benzopyrans

Rearrangement of 3-aryloxy-1-bromo-2-phenylprop-1-enes (3), synthesised from 1,3-bromo 2-phenylprop-1-enes (2) and phenols, in refluxing polyethylene glycol-400 and N,N-diethylaniline gives 3-phenyl-2H-1-benzopyrans (5) in good yields (ca. 70 percent).