1126367-12-1

Upstream product

• 3034-62-6 2-iodo-1H-imidazole 
• 352525-95-2 3-amino-4-methylphenylboronic acid hydrochloride 
• 69383-60-4 5-bromo-2,4-dimethylaniline 
• 16681-56-4 2-bromo-1H-imidazole 
• 850689-28-0 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1126369-31-0 2-(4-methyl-3-nitrophenyl)-1H-imidazole 

Downstream Products

• 1126367-59-6 tert-butyl 4-(5-(1H-imidazol-2-yl)-2-methylphenylcarbamoyl)phenylcarbamate 
• 1126367-40-5 N-(5-(1H-imidazol-2-yl)-2-methylphenyl)-4-((4-chloropyridin-2-yl)methoxy)benzamide 
• 1126368-81-7 N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylethynyl)benzamide 
• 1126366-60-6 N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(1-pyridin-2-ylethoxy)benzamide 
• 1126366-62-8 N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-6-(pyridin-2-ylmethoxy)pyridine-3-carboxamide 
• 1126366-64-0 N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-5-(pyridin-2-ylmethoxy)pyridine-2-carboxamide 
• 1126369-09-2 N-(5-(1H-imidazol-2-yl)-2-methylphenyl)-4-((2-cyanophenoxy)methyl)benzamide 
• 1126369-17-2 N-(5-(1H-imidazol-2-yl)-2-methylphenyl)-4-((3-(4-methylpiperazin-1-yl)pyridin-2-yl)methoxy)benzamide 
• 1126366-94-6 N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-6-phenoxy-pyridine-3-carboxamide 

Relevant academic research and scientific papers

NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS

The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either R2or R3 is (Z).