16681-56-4

Basic information

• Product Name: 2-Bromo-1H-imidazole
• Synonyms: 2-BROMO-1H-IMIDAZOLE;2-Bromoimidazole;2-Bromo-1H-imidazole 98%;1H-Imidazole,2-bromo-(9CI);mo-1H-imidazole;broMo-1H-iMidazole;1H-Imidazole, 2-bromo-;2-Bromo-1H-Imidazole(WX637273)
• CAS NO: 16681-56-4
• Molecular Formula: C₃H₃BrN₂
• Molecular Weight: 146.97
• Product Categories: HALIDE;blocks;Bromides;Imidazoles;Halides;Imidazoles & Benzimidazoles;Imidazole;Imidaxoles;Imidazoles & Benzimidazoles;Halogenated Heterocycles;Heterocyclic Building Blocks;ImidazolesBuilding Blocks;Building Blocks
• Mol File: 16681-56-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 174-182°C
• Boiling Point: 273.1 °C at 760 mmHg
• Flash Point: 119 °C
• Appearance: /
• Density: 1.904 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Keep Cold
• PKA: 11.23±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Bromo-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1H-imidazole(16681-56-4)
• EPA Substance Registry System: 2-Bromo-1H-imidazole(16681-56-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• WGK Germany: 3
• Hazardous Substances Data: 16681-56-4(Hazardous Substances Data)

Usage

Uses

2-Bromoimidazole is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C3H3BrN2/c4-3-5-1-2-6-3/h1-2H,(H,5,6)

Upstream product

• 15469-97-3 N-tritylimidazole 
• 502141-80-2 2,5-dibromo-1⁽³⁾H-imidazole-4-carboxylic acid-(4-bromo-anilide) 
• 10035-10-6 hydrogen bromide 
• 288-32-4 1H-imidazole 
• 1239205-21-0 2-bromo-N,N-dimethyl-1H-imidazole-1-sulfonamide 

Downstream Products

• 876926-04-4 2-bromo-1-[2-(4-chlorophenyl)ethyl]-1H-imidazole 
• 876926-03-3 2-bromo-1-[2-(4-fluorophenyl)ethyl]-1H-imidazole 
• 235426-32-1 1-benzyl-2-bromo-1H-imidazole 
• 1006878-12-1 C₂₁H₂₁N₃O 
• 1126368-07-7 N-(5-(1H-imidazol-2-yl)-2-methylphenyl)-4-(3-methoxybenzyloxy)benzamide 
• 1126366-28-6 N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1126367-12-1 5-(1H-imidazol-2-yl)-2-methylaniline 
• 1126369-77-4 N-[4-fluoro-5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1126368-77-1 N-[2-chloro-5-(1H-imidazol-2-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1190854-01-3 C₂₀H₂₆ClN₅O₃SSi 
• 1185189-50-7 5-(2-bromoimidazol-1-ylmethyl)-4-(3,5-dimethylphenoxy)-3-iodo-6-methylpyridin-2(1H)-one 
• 912962-84-6 3-(3-(bromoimidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide 
• 693-98-1 2-methylimidazole 
• 1207457-15-5 tert-butyl 2-bromo-1H-imidazole-1-carboxylate 

Relevant articles and documents

Preparation method of 2-nitroimidazole

The invention discloses a preparation method of 2-nitroimidazole. The method comprises the following steps: carrying out selective bromination on imidazole as an initial raw material in an imidazole ionic liquid, introducing bromine atoms to the 2-site of the imidazole ring to generate 2-bromoimidazole, and carrying out a nitrosation reaction under the action of a catalyst to obtain 2-nitroimidazole. Based on the defects of difficultly available and expensive raw material 2-aminoimidazole sulfate, risk in use of fluoroboric acid, high copper sulfate consumption and environmental pollution caused by high copper sulfate consumption in the prior art, a new synthesis route is developed, wherein the raw materials are easy to obtain, the steps are short, the cost is low, and the method is environmentally friendly.

INHIBITORS OF POLO-LIKE KINASE

The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions

1-Butyl-3-methylpyridinium tribromide, [BMPy]Br3 proves to be a highly efficient, regioselective reagent/solvent for nuclear bromination of various anilines and phenols. The synthesis and characterization of the room temperature ionic liquid [BMPy]Br3 (2) is described. The bromination was carried out in the absence of organic solvents and in most cases the only extraction solvent needed was water. The spent 1-butyl-3-methylpyridinium bromide (1) was easily recycled.