112641-29-9

Basic information

• Product Name: 3-cyclobutyl 5-methyl 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-((2-((2-(cyclobutyloxycarbonyl)benzoyl)amino)ethoxy)methyl)-6-(fluoromethyl)-1,4-dihydro-3,5-pyridinedicarboxylate
• Synonyms: 3-cyclobutyl 5-methyl 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-((2-((2-(cyclobutyloxycarbonyl)benzoyl)amino)ethoxy)methyl)-6-(fluoromethyl)-1,4-dihydro-3,5-pyridinedicarboxylate
• CAS NO: 112641-29-9
• Molecular Weight: 741.109
• Mol File: 112641-29-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-cyclobutyl 5-methyl 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-((2-((2-(cyclobutyloxycarbonyl)benzoyl)amino)ethoxy)methyl)-6-(fluoromethyl)-1,4-dihydro-3,5-pyridinedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclobutyl 5-methyl 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-((2-((2-(cyclobutyloxycarbonyl)benzoyl)amino)ethoxy)methyl)-6-(fluoromethyl)-1,4-dihydro-3,5-pyridinedicarboxylate(112641-29-9)
• EPA Substance Registry System: 3-cyclobutyl 5-methyl 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-((2-((2-(cyclobutyloxycarbonyl)benzoyl)amino)ethoxy)methyl)-6-(fluoromethyl)-1,4-dihydro-3,5-pyridinedicarboxylate(112641-29-9)

Safety Data

• Hazardous Substances Data: 112641-29-9(Hazardous Substances Data)

Upstream product

• 112641-33-5 2-((2-((2-Carboxybenzoyl)amino)ethoxy)methyl)-4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-6-(fluoromethyl)-1,4-dihydro-5-(methoxycarbonyl)-3-pyridinecarboxylic acid 
• 2919-23-5 cyclobutanol 
• 10026-13-8 phosphorus pentachloride 

Relevant articles and documents

Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof

There are described compounds of Formula I, in which R1, R2, R3 and R4 are as defined in the specification,R5 is alkyl optionally interrupted by an amide group and optionally substituted by halogen or by a carboxy or a heterocyclic group,X is -O-, -NR-, -S(O)m1, or a bond,Z is hydrogen or together with R forms a bond,R is hydrogen, alkyl or together with Z forms a bond,R6 is a 5 or 6 membered unsaturated nitrogen containing heterocyclic ring, optionally fused to a phenyl ring and optionally substituted by one or more of oxo, hydroxy, alkyl, -(CH2)n1NH2, alkoxy, phenyl or -COOH,and when X is -NR- or -S(O)m1-, R6 may in addition be hydrogen or a group -CH2CH2NH2, -CH2CH2-het. or NHC(=NH)NH2,when X is -O-, R6 may also be a group -NH2, -C(=O) (CH2)nNH2, -CH2CH2NR14R15 or CH2CH2OCH2CH2NR14R15,when X is -NR-, -S(O)m1-, or a bond, R6 may also be hydrogen or a group -C(=NR12)NHR13,R13 and R14 may be hydrogen or alkyl,R12 is hydrogen, alkylcarbonyl, nitrile or hydroxy,R15 is hydrogen or a group R11,m and m1 are each 0, 1 or 2,n is 0 or 1,n1 is an integer from 0 to 6, and pharmaceutically acceptable salts, esters, amides, analogues and protected derivatives thereof.