1126444-37-8

Upstream product

• 145474-62-0 1-methoxycarbonyl-benzoindolizine 
• 98-09-9 benzenesulfonyl chloride 
• 1126444-15-2 C₁₄H₁₀ClNO₂ 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Desulfitative palladium-catalyzed direct C-3 arylation of indolizines with arylsulfonyl chlorides

An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1-methyl-2-pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C-3 arylation of indolizines. An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, the protocol using readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation proceeds in a mixed solvent of NMP and DME using simple triphenylphosphine a ligand, and provides a new method for the C-3 arylation of indolizines.

Synthesis of 3-Haloindolizines by copper(ii) halide mediated direct functionalization of indolizines

3-Haloindolizines were synthesized via Cu(II) halide mediated halogenation of indolizines. This C-H direct functionalization process occurred under mild conditions giving 3-haloindolizines in moderate to excellent yields, and the products obtained were tested under the Suzuki-Miyaura reaction providing 3-arylindolizines in high yields.