112655-31-9

Usage

Imidazole derivative

contains an imidazole ring, a five-membered ring with two nitrogen atoms.

Substituents

a methoxymethyl group (-OCH3) and a phenyl group (-C6H5)

Common uses

building block in the synthesis of pharmaceuticals and organic compounds, reagent in organic synthesis, ligand in coordination chemistry

Reactivity

can act as a nucleophile and a base due to the presence of the imidazole ring.

Upstream product

• 670-96-2 2-Phenylimidazole 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 865688-96-6 5-iodo-1-methoxymethyl-2-phenyl-1H-imidazole 
• 1318212-36-0 2-phenylimidazole-4-yldiphenylphosphine 
• 1350849-10-3 C₂₃H₂₁N₂OP 
• 119336-47-9 3-(2-Phenyl-3H-imidazol-4-yl)-2,2-bis-(2-phenyl-3H-imidazol-4-ylmethyl)-propionitrile; hydrochloride 
• 119336-45-7 tris<<1-(methoxymethyl)-2-phenyl-5-imidazolyl>methyl>acetonitrile 
• 119336-40-2 5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride 
• 119336-39-9 5-(hydroxymethyl)-1-(methoxymethyl)-2-phenylimidazole 
• 865688-98-8 1-[2-(1-methoxymethyl-2-phenyl-1H-5imidazolyl)]-1-ethanone 

Relevant academic research and scientific papers

Gold(I) catalysts with bifunctional P, N ligands

A series of phosphanes with imidazolyl substituents were prepared as hemilabile PN ligands. The corresponding gold(I) complexes were tested as bifunctional catalysts in the Markovnikov hydration of 1-octyne, as well as in the synthesis of propargylamines by the three component coupling reaction of piperidine, benzaldehyde, and phenylacetylene. While the activity in the hydration of 1-octyne was low, the complexes are potent catalysts for the three component coupling reaction. In homogeneous solution the conversions to the respective propargylamine were considerably higher than under aqueous biphasic conditions. The connectivity of the imidazolyl substituents to the phosphorus atom, their substitution pattern, as well as the number of heteroaromatic substituents have pronounced effects on the catalytic activity of the corresponding gold(I) complexes. Furthermore, formation of polymetallic species with Au2, Au3, and Au4 units has been observed and the solid-state structures of the compounds [(5)2Au 3Cl2]Cl and [(3c)2Au4Cl 2]Cl2 (3c = tris(2-isopropylimidazol-4(5)-yl phosphane, 5 = 2-tert-butylimidazol-4(5)-yldiphenyl phosphane) were determined. The gold(I) complexes of imidazol-2-yl phosphane ligands proved to be a novel source for bis(NHC)gold(I) complexes (NHC = N-heterocyclic carbene).