112675-13-5Relevant academic research and scientific papers
NOVEL HETEROAROMATIC DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 25, (2010/06/19)
The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors-subtype 4 (?mGluR4?) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved
NOVEL HETEROAROMATIC DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 60-61, (2009/03/07)
The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am and
On the Chemistry of Pyrazolylalkines; Pyrazoles II.
Heinisch, Gottfried,Holzer, Wolfgang,Obala, Claudia
, p. 253 - 262 (2007/10/02)
Palladium-catalyzed reactions of 1-benzoyl-4-iodopyrazole (2a) with monosubstituted acetylenes 3a,3b and 3c in triethylamine solution provide convenient access to the cross-coupled products 4a,4b and 4c.The 4-ethinylpyrazoles 5a and 7 obtained after metha
Pyrazole Chemistry I: Efficient Syntheses of Aryl or Benzyl 4-Pyrazolyl Ketones and Carbinols
Heinisch, Gottfried,Holzer, Wolfgang,Huber, Thierry
, p. 1267 - 1272 (2007/10/02)
Dilithiation of 4-bromopyrazole followed by reaction with appropriate electrophiles provides an improved access to 4-benzoylpyrazole (3) and the corresponding alcohol 4a.In a similar manner the homologous compounds 5 and 7 are conveniently available.
