82099-93-2Relevant academic research and scientific papers
Ethyl vinyl ether - An agent for protection of the pyrazole NH-fragment. A convenient method for the preparation of N-unsubstituted 4-alkynylpyrazoles
Vasilevsky, Sergei F.,Klyatskaya, Svetlana V.,Tretyakov, Eugene V.,Elguero, José
, p. 879 - 886 (2007/10/03)
N-Unsubstituted 4-iodopyrazole (1) is easily converted into 4-alkynyl derivatives (5) in moderate to good overall yields by using intermediate protection of the nitrogen atom of the pyrazole ring by ethyl vinyl ether.
A convenient synthesis of alkynylpyrazoles
Yoshimatsu, Mitsuhiro,Kawahigashi, Masataka,Honda, Eiji,Kataoka, Tadashi
, p. 695 - 700 (2007/10/03)
Diazomethane add to the enyne sulfones 1,3,4,6-11 regio- and stereo-selectively to give the 4-alkynyl-5-phenylsulfonyl-4,5-dihydro-3H-pyrazoles 12-15 and 17-19, which are converted by MeLi into the 4-alkynyl-1H-pyrazoles 24, 25, 16, 26, 28, 30 in good yields. 4,5-Bis(alkynyl)-1H-pyrazoles 34, 37 are also obtained by the same procedure.
On the Chemistry of Pyrazolylalkines; Pyrazoles II.
Heinisch, Gottfried,Holzer, Wolfgang,Obala, Claudia
, p. 253 - 262 (2007/10/02)
Palladium-catalyzed reactions of 1-benzoyl-4-iodopyrazole (2a) with monosubstituted acetylenes 3a,3b and 3c in triethylamine solution provide convenient access to the cross-coupled products 4a,4b and 4c.The 4-ethinylpyrazoles 5a and 7 obtained after metha
Synthetic inhibitors of alcohol dehydrogenase. Pyrazoles containing an unsaturated hydrocarbon residue in the 4-position.
Tolf,Dahlbom,Theorell,Akeson
, p. 101 - 107 (2007/10/02)
A series of pyrazoles containing an unsaturated hydrocarbon residue in the 4-position has been synthesized and tested for ability to inhibit the activity of the enzyme liver alcohol dehydrogenase. These compounds were found to be less active than the corr
