112677-72-2

Basic information

• Product Name: 3-(2-MORPHOLIN-4-YLETHOXY)ANILINE
• Synonyms: ASINEX-REAG BAS 16339126;3-(2-MORPHOLIN-4-YLETHOXY)ANILINE;3-(2-MORPHOLIN-4-YL-ETHOXY)-PHENYLAMINE;AKOS BC-0116;TIMTEC-BB SBB011498;3-(2-Morpholin-4-ylethoxy)aniline 95%;Benzenamine,3-[2-(4-morpholinyl)ethoxy]-;3-(2-MORPHOLIN-4-YLETHOXY)ANILINE(WX602078)
• CAS NO: 112677-72-2
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.28
• Mol File: 112677-72-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 395.9 °C at 760 mmHg
• Flash Point: 193.2 °C
• Appearance: /
• Density: 1.129 g/cm³
• Vapor Pressure: 1.78E-06mmHg at 25°C
• Refractive Index: 1.557
• PKA: 6.52±0.10(Predicted)
• CAS DataBase Reference: 3-(2-MORPHOLIN-4-YLETHOXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-MORPHOLIN-4-YLETHOXY)ANILINE(112677-72-2)
• EPA Substance Registry System: 3-(2-MORPHOLIN-4-YLETHOXY)ANILINE(112677-72-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 112677-72-2(Hazardous Substances Data)

Usage

General Description

3-(2-Morpholin-4-ylethoxy)aniline is a chemical compound from the family of Morpholines. Morpholines are organic compounds that contain a ring structure, which includes an oxygen, a nitrogen atom, and four carbon atoms. This specific compound, 3-(2-Morpholin-4-ylethoxy)aniline, has potential applications in the pharmaceutical industry, as it can potentially be used to synthesize various drugs due to its chemical structure. However, it is always essential to handle such chemicals with care due to possible toxicity or other potential hazards associated with their use or disposal. The detailed properties such as melting point, boiling point, density, and molecular weight depend on its variants and can be obtained from the Chemical Abstracts Service (CAS) database.

InChI:InChI=1/C12H18N2O2/c13-11-2-1-3-12(10-11)16-9-6-14-4-7-15-8-5-14/h1-3,10H,4-9,13H2

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 621-42-1 meta-hydroxyacetanilide 
• 3240-94-6 N-(2-chlorethyl)morpholine 
• 182618-90-2 3-[2-(N-Morpholino)ethoxy]-1-nitrobenzene 
• 554-84-7 meta-nitrophenol 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 373826-61-0 N-3-cyanocyclopentyl-4-(2-(3-amino-phenoxy)ethyl)morpholine 
• 373825-51-5 N-(4-fluorophenylmethyl)-4-(2-(3-aminophenoxy)ethyl)morpholine 
• 1573024-82-4 1-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea 
• 1571073-60-3 1-(4-((2-((3-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea 
• 1256163-23-1 5-(3-(2-morpholinoethoxy)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde 
• 1139717-55-7 [5-(3-Dimethylaminophenoxy)-pyridin-2-yl]-[3-(2-morpholin-4-yl-ethoxy)phenyl]amine 
• 1139717-45-5 5-(3,4-difluorophenoxy)-pyridin-2-yl-[3-(2-morpholin-4-ylethoxy)-phenyl]amine 
• 929267-46-9 C₂₀H₂₂N₄O₃ 
• 112677-74-4 [3-[2-(4-Morpholinyl)ethoxy]phenyl]guanidine monohydrochloride 
• 182618-66-2 N-[3(R)-5-Cyclohexyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'-[3-(2-(N-morpholino)ethoxy)phenyl]urea 
• 223442-31-7 C₂₇H₃₂Cl₃N₃O₃ 

Relevant articles and documents

Synthesis and anti-proliferative activity of substituted- anilinoquinazolines and its relation to EGFR inhibition

4-Anilinoquinazoline is a privileged scaffold in developing small molecule inhibitors of tyrosine kinases (TK) especially epidermal growth factor receptor (EGFR). 2 series belonging to 3'-substituted-4-anilinoquinazoline scaffold were synthesized and screened in vitro on isolated and a breast cancer cell line. The research aims at exploring the activity of compounds having diverse substituents at 3' position of the aniline moiety. Generally, the meta-substituted-anilinoquinazolines exhibited significant inhibitory activity against isolated enzyme as well as MCF-7 cancer cell line. For instance, compound 10b inhibited >99% of EGFR activities at 10 M concentration. 6 of the tested compounds exhibited range of anti-proliferative activity below 10 M potency. In particular, compounds 6e and 10b displayed the highest activity among the tested compounds with IC50 values equal to 8.6 and 4.84 M, respectively. Structure-based tools were utilized to rationalize EGFR-TK binding of compound 10b since it is the most active compound in the enzyme inhibition test. Georg Thieme Verlag KG Stuttgart.New York.

2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors

The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

CYCLOPENTENE DERIVATIVES USEFUL AS ANTAGONISTS OF THE MOTILIN RECEPTOR

The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.