1126793-08-5Relevant academic research and scientific papers
Decarboxylative allylation of amino alkanoic acids and esters via dual catalysis
Lang, Simon B.,O'Nele, Kathryn M.,Tunge, Jon A.
, p. 13606 - 13609 (2014)
A combination of photoredox and palladium catalysis has been employed to facilitate the room temperature decarboxylative allylation of recalcitrant amino and phenylacetic allyl esters. This operationally simple process produces CO2as the only b
Intramolecular carbolithiation reactions for the synthesis of 2,4-disubstituted tetrahydro-quinolines: Evaluation of TMEDA and (-)-sparteine as ligands in the stereoselectivity
Martinez-Estibalez, Unai,Sotomayor, Nuria,Lete, Esther
supporting information; experimental part, p. 1237 - 1240 (2009/08/12)
The preparation of 4-substituted 2-phenyltetrahydroquinolines from N-alkenylsubstituted 2-iodoanilines via intramolecular carbolithiation reactions has been investigated. The stereochemical outcome of the carbolithiation reactions depends on the nature of organolithium employed to perform the lithium-halogen exchange, the solvent, or the use of additives, for example, TMEDA or chiral bidentated ligands such as (-)-sparteine. Thus, the 2,4-disubstituted tetrahydroquinolines are obtained with moderate diastereoselectivities (up to 77:23) and with ee up to 94% when Weinreb amide derivatives are used (R) CONMe(OMe)).
