1126906-41-9Relevant academic research and scientific papers
Enantioselective michael reaction of malonates and αβ- unsaturated aldehydes using a trans-4-hydroxyproline derived organocatalyst
Sato, Hisayuki,Nagashima, Fumiaki,Oriyama, Takeshi
experimental part, p. 379 - 381 (2010/07/06)
Asymmetrie Michael addition of malonates to various α, βunsaturated aldehydes using an organocatalyst derived from trans-4-hydroxyproline in MeOH proceeds smoothly to afford the corresponding Michael adducts in high yields with high to excellent enantioselectivities.
Base-base bifunctional catalysis: A practical strategy for asymmetric Michael addition of malonates to α,β-unsaturated aldehydes
Wang, Yongcan,Li, Pengfei,Liang, Xinmiao,Yea, Jinxing
supporting information; experimental part, p. 1383 - 1389 (2009/06/18)
Lewis base-Bronsted base bifunctional catalysis is a novel and practical strategy for the asymmetric Michael addition. The addition of malonates to a series of α,β-unsaturated aldehydes can take place under base-base bifunctional catalytic conditions using 0.5-5 mol% of (S)-2-[diphenyl(trimethylsilyloxy) methyl]pyrrolidine as catalyst and 5-30 mol% of lithium 4-fluorobenzoate as additive base with up to 99% ee.
