112700-36-4

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 142955-51-9 N-butoxycarbonyl-L-phenylalanine anhydride 
• 4530-18-1 N-(tert-butoxycarbonyl)-L-phenylalanine 

Downstream Products

• 69358-30-1 (5S)-5-benzylpyrrolidine-2,4-dione 
• 1373825-26-3 (S)-2-benzyl-5-oxo-2,5-dihydro-1H-3-pyrrolyl benzoate 
• 1373825-33-2 (S)-2-benzyl-5-oxo-2,5-dihydro-1H-3-pyrrolyl 2-methylbutanoate 
• 1373825-38-7 (S)-5-benzyl-3-(α-hydroxybenzylidene)-4-oxo-2-pyrrolidone 
• 1373825-58-1 (S)-5-benzyl-3-(α-hydroxybenzylidene)-4-oxo-2-pyrrolidone 
• 1373825-48-9 (S)-5-benzyl-3-(1-hydroxy-2-methylbutylidene)-4-oxo-2-pyrrolidone 
• 1373825-68-3 (S)-5-benzyl-3-(1-hydroxy-2-methylbutylidene)-4-oxo-2-pyrrolidone 
• 109579-09-1 (5S)-5-benzyl-4-hydroxy-1-t-butoxycarbonylpyrrol-2(5H)-one 

Relevant academic research and scientific papers

Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics

Oligo-pyrrolinone-pyrrolidines (generic structure 1) have the potential to interfere with protein-protein interactions (PPIs), but to reduce this to practice it is necessary to be able to synthesize these structures with a variety of different side chains

A synthetic approach to diverse 3-acyltetramic acids via O- to C-acyl rearrangement and application to the total synthesis of penicillenol series

For the efficient approach to medicinally important α-branched 3-acyltetramic acids, the key reaction of O- to C- acyl rearrangement using α-amino-acid-derived 4-O-acyltetramic acids was extensively examined in the presence of various metal salts. Use of

Synthesis of acylated active methylene compounds with N-boc-L-phenylalanine and their heterocyclization, both achieved enantioselectively

Three active methylene compounds, malononitrile, methyl cyanoacetate and Meldrum's acid, have been found to be acylated effectively with N-Boc-L-phenylalanine using carbonyldiimidazole (CDI) activation conditions. Two of the aminoacetyl derivatives isolat

Synthesis of N-substituted 3-ammomethylidenetetramic acids

(S)-3-(Dimethylamino)methylidene-5-benzyltetramic acid derivatives 4a and 4b were prepared in three steps from N-protected (S)-3-phenylalanines 1a and 1b, respectively. Similarly, N-[N-(benzyloxycarbonyl)glycyl]grycine (1c) was transformed into the enamitione 4c. Acid-catalysed coupling of enaminones 4a-c with aliphatic, aromatic, and heteroaromatic primary amines 5-34 afforded the corresponding N(3′)-substituted 3-aminomethylidenetetramic acid derivatives 35-64 in 29-96% yields. Georg Thieme Verlag Stuttgart.

Design of potential new HIV protease inhibitors: Enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates

Novel potential HIV protease inhibitors are obtained by an enantioconvergent synthesis of mimicking Phe-Pro dipeptides, achieved through the coupling between Boc(L)Phe or Boc(L)Tyr and both enantiomers of syn-2-benzylpyrrolidin-3-ol and their correspondin

Synthesis of Chiral Urethane N-Alkoxycarbonyl Tetramic Acids from Urethane N-Carboxyanhydrides (UNCAs)

The synthesis of chiral N-protected tetramic acid derivatives which are precursors of β-hydroxy γ-amino acid under mild conditions is described.Reaction of urethane-N-carboxyanhydrides (UNCAs) with Meldrum's acid in the presence of a tertiary amine, follo

Stereospecific Synthesis of N-Protected Statine and Its Analogues via Chiral Tetramic Acid

The condensation of a chiral N-protected amino acid with Meldrum's acid in the presence of isopropenyl chloroformate (IPCF) and of 4-N,N-dimethylaminopyridine (DMAP) has been examined.The cyclisation of the reaction product, by heating in an organic solve