112704-80-0

Basic information

• Product Name: ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate
• Synonyms: ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate;3-(4-BROMO-2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• CAS NO: 112704-80-0
• Molecular Formula: C₁₁H₁₀BrFO₃
• Molecular Weight: 289.0977032
• EINECS: -0
• Mol File: 112704-80-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 329.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.487±0.06 g/cm3(Predicted)
• PKA: 9.74±0.48(Predicted)
• CAS DataBase Reference: ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate(112704-80-0)
• EPA Substance Registry System: ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate(112704-80-0)

Safety Data

• Hazardous Substances Data: 112704-80-0(Hazardous Substances Data)

Upstream product

• 6148-64-7 ethyl potassium malonate 
• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 1071-46-1 hydrogen ethyl malonate 
• 151982-51-3 4-bromo-2-fluorobenzoyl chloride 

Downstream Products

• 1204536-76-4 2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester 
• 1429510-21-3 ethyl 5-(4-bromo-2-fluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate 
• 1429510-96-2 ethyl 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate 
• 1429510-97-3 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide 
• 1429511-03-4 ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1429511-04-5 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylic acid 
• 1429511-05-6 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxamide 
• 1429510-34-8 ethyl 5-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1429510-33-7 ethyl 5-(4-bromo-2-fluorophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 

Relevant articles and documents

SALT OF PYRAZOLOQUINOLINE DERIVATIVE, AND CRYSTAL THEREOF

The present invention provides a salt of (S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-pyrazolo[4,3-c]quinolin-4(5H)-one and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric

PYRAZOLOQUINOLINE DERIVATIVES

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has applicability as a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.