ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate
CAS No.:112704-80-0
Molecular Formula:C11H10BrFO3
Molecular Weight:289.101
Hs Code.:
Mol file:112704-80-0.mol

Synonyms:ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Suppliers and Price of ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-(4-Bromo-2-fluorophenyl)-3-oxopropionic acid ethyl ester 95%
5g
$ 1403.00

Labseeker
3-(4-BROMO-2-FLUORO-PHENYL)-3-OXO-PROPIONICACIDETHYLESTER 95
1g
$ 1283.00

American Custom Chemicals Corporation
3-(4-BROMO-2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 95.00%
5G
$ 1029.02

American Custom Chemicals Corporation
3-(4-BROMO-2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 95.00%
1G
$ 678.66

Total 6 raw suppliers

Chemical Property of ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Chemical Property:

Boiling Point:329.9±32.0 °C(Predicted)
PKA:9.74±0.48(Predicted)
PSA：43.37000
Density:1.487±0.06 g/cm3(Predicted)
LogP:2.72410

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Bromo-2-fluorophenyl)-3-oxopropionic acid ethyl ester 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

There total 3 articles about ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1071-46-1
hydrogen ethyl malonate

: 151982-51-3
4-bromo-2-fluorobenzoyl chloride

: 112704-80-0
ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Guidance literature:: hydrogen ethyl malonate; With n-butyllithium; In tetrahydrofuran; at -50 - 0 ℃; Inert atmosphere;

4-bromo-2-fluorobenzoyl chloride; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 6148-64-7
ethyl potassium malonate

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 112704-80-0
ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Guidance literature:: 2-fluoro-4-bromobenzoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 10 - 35 ℃; for 3.5h;

ethyl potassium malonate; With triethylamine; magnesium chloride; In dichloromethane; acetonitrile; at 10 - 35 ℃;

With hydrogenchloride; In water; ethyl acetate; at 10 - 35 ℃; for 1h; Cooling with ice;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 112704-80-0
ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -50 - 0 °C / Inert atmosphere

2.2: 16 h / 20 °C

With n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;