112724-00-2

Basic information

• Product Name: 1-methyl-2-phenyl-3-(4-methoxyphenyl)-1H-indole
• Synonyms: 1-methyl-2-phenyl-3-(4-methoxyphenyl)-1H-indole
• CAS NO: 112724-00-2
• Molecular Weight: 313.399
• Mol File: 112724-00-2.mol

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-phenyl-3-(4-methoxyphenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-phenyl-3-(4-methoxyphenyl)-1H-indole(112724-00-2)
• EPA Substance Registry System: 1-methyl-2-phenyl-3-(4-methoxyphenyl)-1H-indole(112724-00-2)

Safety Data

• Hazardous Substances Data: 112724-00-2(Hazardous Substances Data)

Upstream product

• 5834-42-4 3-(4-methoxyphenyl)-2-phenyl-1H-indole 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 696-62-8 para-iodoanisole 
• 54655-08-2 N,N-dimethyl-2-(2-phenylethynyl)aniline 
• 536-74-3 phenylacetylene 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 542-11-0 aniline hydrobromide 
• 62-53-3 aniline 

Downstream Products

• 6916-99-0 4-(1-methyl-2-phenyl-1H-indol-3-yl)phenol 

Relevant articles and documents

Palladium-Catalyzed Synthesis of 2,3-Diaryl- N-methylindoles from ortho-Alkynylanilines and Aryl Pinacol Boronic Esters

A palladium-catalyzed synthesis of 2,3-diaryl-N-methylindoles from o-alkynylanilines and aryl pinacol boronic esters was developed. The system possesses high functional group tolerance and a broad substrate scope with a variety of aryl pinacol boronic est

Au-promoted Pd-catalyzed arylative cyclization of N,N-dimethyl-o-alkynylaniline with aryl iodides: Access to 2,3-diaryl indoles and mechanistic insight

We have developed a Au-promoted Pd-catalyzed cyclization/cross-coupling of N,N-dimethyl-o-alkynylaniline with aryl iododes to synthesize 2,3-diarylindoles under mild and base-free conditions. A related vinyl-Au species has been isolated through Au-promoted cyclization of N,N-dimethyl-o-alkynylaniline and structurally characterized. Further study on its reactivity suggests the vinyl-Au species might be out of catalytic cycle, and PhPd(OTf)(PPh3)2 is probably the reaction intermediate.

Pd/phenanthroline-catalyzed arylative cyclization of o-(1-alkynyl)thioanisoles: Synthesis of 3-arylated benzo[b]thiophenes

The arylative cyclization of o-(1-alkynyl)thioanisoles with aryl iodides in the presence of catalytic amounts of [Pd(phen)2][PF6]2resulted in the efficient formation of 3-arylated benzo[b]thiophenes, and a range of aryl iodides with electron-donating or -withdrawing groups could be used. While this reaction proceeded in the presence of aromatic and aliphatic groups on the terminal alkynyl carbon atom, silyl and alkoxycarbonyl groups hampered the reaction. Furthermore, this method could be extended to the synthesis of 3-arylated indoles from N,N-dimethyl-o-(1-alkynyl)aniline. All these reactions proceeded smoothly via cleavage of the carbon-heteroatom bond. In addition to the desired cyclization products, the use of a o-(hydroxypropyl)phenylmethyl substituent on the sulfur atom afforded isochroman, which should be formed by the intramolecular attack of a hydroxy group onto the benzylic carbon atom.

Indole compounds and their use as estrogen agonists/antagonists

This invention relates to compounds, in particular indoles, that are useful as estrogen agonists and antagonists and pharmaceutical uses thereof. The present invention also relates to indoles that are selective for the ERβ receptor and pharmaceutical uses