112734-89-1

Basic information

• Product Name: 6-AMINO-1,3-DIMETHYLPYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
• Synonyms: Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-amino-1,3-dimethyl-;6-Amino-1,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione
• CAS NO: 112734-89-1
• Molecular Formula: C₉H₁₀N₄O₂
• Molecular Weight: 206.2
• Mol File: 112734-89-1.mol

Chemical Properties

• Boiling Point: 459.5°Cat760mmHg
• Flash Point: 231.7°C
• Appearance: /
• Density: 1.403g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 6-AMINO-1,3-DIMETHYLPYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-1,3-DIMETHYLPYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE(112734-89-1)
• EPA Substance Registry System: 6-AMINO-1,3-DIMETHYLPYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE(112734-89-1)

Safety Data

• Hazardous Substances Data: 112734-89-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10N4O2/c1-12-7-6(3-5(10)4-11-7)8(14)13(2)9(12)15/h3-4H,10H2,1-2H3

Upstream product

• 2434-53-9 6-amino-1-methyluracil 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 112734-86-8 1,3-dimethyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione 
• 142168-86-3 1-methyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione 

Downstream Products

• 142168-93-2 6-benzylamino-1-methylpyrido<2,3-d>pyrimidine-2,4-dione 
• 142168-92-1 6-benzylideneimino-1-methylpyrido<2,3-d>pyrimidine-2,4-dione 

Relevant articles and documents

Design, synthesis and transformation of some heteroannulated 3-aminopyridines - Purine isosteres with exocyclic nitrogen atom

The synthesis of 1-deazapurines and isosteres bearing the exocyclic nitrogen atom at position-1 was developed basing on the formal [3+3]-cyclization reaction of nitro-malonaldehyde with the set of electron-excessive aminoheterocycles. Through the function

Bronchodilating pyrido?2,3-d!pyrimidine derivatives

A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido?2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts or metal complexes thereof as an effective component: STR1 wherein R1 and R2 are the same or different and each of R1 and R2 is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or --NH--X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino. The rapid-acting remedy for bronchial asthma is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action. It can be used as a therapy not only for allergic asthma but also for various bronchial asthmas such as endogenous asthma, exogenous asthma and dust asthma.

PYRIMIDINES, XXXII: SYNTHESIS AND PROPERTIES OF PYRIDOPYRIMIDINE-2,4-DIONES (5-DEAZALUMAZINES)

Pyridopyrimidine-2,4-dione (8) and its N-methyl derivatives (9-11) as well as the corresponding 6-nitro analogues (12-15) have been synthesized by condensation reactions from 6-aminouracils (4-7).Reduction of compound (4-7) led to the 6-aminopyrido

5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): STR1 wherein each of R1 and R2, which may be the same or different, is a lower alkyl group; and each of R3 and R4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.